The term minimal hepatic encephalopathy refers to the subtle changes in cognitive function,
electrophysiological parameters, cerebral neurochemical/neurotransmitter homeostasis …

Aliment Pharmacol Ther 2011; 33: 739–747 Summary Background The clinical classification
of hepatic encephalopathy is largely subjective, which has led to difficulties in designing …

Background Non‐absorbable disaccharides (lactulose and lactitol) are recommended as
first‐line treatment for hepatic encephalopathy. The previous (second) version of this review …

Alcohol misuse is the leading cause of cirrhosis and the second most common indication for
liver transplantation in the Western world,,. We performed a genome-wide association study …

Nitrogen metabolism plays a major role in the development of hepatic encephalopathy (HE)
in patients with cirrhosis. Modulation of this relationship is key to the management of HE, but …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …

Background: A number of clinical trials have been undertaken to determine the efficacy of
acamprosate in the maintenance of abstinence in alcohol‐dependent individuals. However …

Background Although malnutrition and sarcopenia are prevalent in cirrhosis, their impact on
outcomes following liver transplantation is not well documented. Methods The associations …

The opioid antagonist, naltrexone, is reported, in single centre studies, to improve the
clinical outcome of individuals with alcohol dependence participating in outpatient …

Accurate assessments of nutritional status are difficult to obtain in patients with cirrhosis. The
aim of this study was to devise and validate a global nutritional assessment scheme for use …