Gliomas develop in unique and complicated environments that nourish tumor cells. The
tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain …

Background As lymphatic vessel is a major route for solid tumor metastasis, they are
considered an essential part of tumor drainage conduits. Apart from forming the walls of …

The tumor microenvironment (TME) is critical for tumor progression. However, the
establishment and function of the TME remain obscure because of its complex cellular …

Gut microbiota is proven to be involved in the development of beta amyloid (Aβ) pathology in
Alzheimer's disease (AD). Since there are difficulties in translating microbiota findings based …

Glioblastoma (GBM) is the most common malignant primary tumor in the central nervous
system. Despite advances in neurosurgery, radiation therapy and chemotherapy, the …

Scope Decreasing β‐amyloid (Aβ) accumulation is of significance in finding therapeutic
candidates for cognitive impairments in Alzheimer's disease (AD). The aim of this study is to …

The modulation of xanthine oxidase (XO) activity is critical to the treatment of hyperuricemia
and oxidative stress-related disease. Although the walnut protein hydrolysates had been …

Hyperuricemia is a metabolic disease caused by disorders of purine metabolism, the
prevalence of which has increased worldwide. Here, a cell model for high uric acid …

Wnt signaling pathway is an evolutionarily conserved pathway that control embryonic
development, adult tissue homeostasis, and pathological processes of organisms …

Hyperuricemia (HUA) is a metabolic disorder caused by abnormal purine metabolism, the
prevalence of which has increased worldwide. Here, a 3D organoid culture system for …