Background & Aims Countries endemic for parasitic infestations have a lower incidence of
Crohn's disease (CD) than nonendemic countries, and there have been anecdotal reports of …

Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC),
results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies …

Ubiquitination functions as a sorting signal for lysosomal degradation of cell-surface proteins
by facilitating their internalization from the plasma membrane and incorporation into lumenal …

Introduction Biomarkers are needed in inflammatory bowel disease (IBD) to help define
disease activity and identify underlying pathogenic mechanisms. We hypothesized that …

Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host,
and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in …

EGFR signaling regulates macrophage function, but its role in bacterial infection has not
been investigated. Here, we assessed the role of macrophage EGFR signaling during …

Background & Aims Because inflammatory bowel disease is increasing worldwide and can
lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown …

CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has
been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is …

Helicobacter pylori infection is the main risk factor for the development of gastric cancer, the
third leading cause of cancer death worldwide. H. pylori colonizes the human gastric …

Summary The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory
and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched …