User profiles for "author:Mark A Valasek"

Mark A Valasek

Professor of Pathology, University of California San Diego
Verified email at ucsd.edu
Cited by 11010

The power of real-time PCR

MA Valasek, JJ Repa - Advances in physiology education, 2005 - journals.physiology.org
In recent years, real-time polymerase chain reaction (PCR) has emerged as a robust and
widely used methodology for biological investigation because it can detect and quantify very …

An update on the diagnosis, grading, and staging of appendiceal mucinous neoplasms

MA Valasek, RK Pai - Advances in anatomic pathology, 2018 - journals.lww.com
Despite advances in our understanding of appendiceal mucinous neoplasms and their
relationship to the pseudomyxoma peritonei syndrome, the classification of mucinous tumors …

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Y Xiong, N Miyamoto, K Shibata… - Proceedings of the …, 2004 - National Acad Sciences
Leptin is an adipose-derived hormone that regulates a wide variety of physiological
processes, including feeding behavior, metabolic rate, sympathetic nerve activity …

Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven …

CC Park, P Nguyen, C Hernandez, R Bettencourt… - Gastroenterology, 2017 - Elsevier
Background & Aims Magnetic resonance imaging (MRI) techniques and ultrasound-based
transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in …

[PDF][PDF] ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

H Nakagawa, A Umemura, K Taniguchi… - Cancer cell, 2014 - cell.com
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral
hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) …

[PDF][PDF] Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer

J Font-Burgada, S Shalapour, S Ramaswamy, B Hsueh… - Cell, 2015 - cell.com
Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration
and maintenance but also promotes development of hepatocellular carcinoma (HCC) …

[PDF][PDF] p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells

A Umemura, F He, K Taniguchi, H Nakagawa… - Cancer cell, 2016 - cell.com
Summary p62 is a ubiquitin-binding autophagy receptor and signaling protein that
accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs) …

Development and validation of a histological index for UC

MH Mosli, BG Feagan, G Zou, WJ Sandborn… - Gut, 2017 - gut.bmj.com
Objective Although the Geboes score (GS) and modified Riley score (MRS) are commonly
used to evaluate histological disease activity in UC, their operating properties are unknown …

[PDF][PDF] Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a …

R Loomba, CB Sirlin, B Ang, R Bettencourt, R Jain… - …, 2015 - Wiley Online Library
Ezetimibe inhibits intestinal cholesterol absorption and lowers low‐density lipoprotein
cholesterol. Uncontrolled studies have suggested that it reduces liver fat as estimated by …

Histopathology scoring systems of stenosis associated with small bowel Crohn's disease: a systematic review

IO Gordon, D Bettenworth, A Bokemeyer, A Srivastava… - Gastroenterology, 2020 - Elsevier
Background & Aims Stenosis is a common complication of Crohn's disease (CD) that has no
effective medical therapy. Development of antifibrotic agents will require testing in …