User profiles for "author:Matthias Laudes"

Matthias Laudes

University of Kiel (Germany)
Verified email at uksh.de
Cited by 7988

[HTML][HTML] Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis

M Pinart, A Dötsch, K Schlicht, M Laudes, J Bouwman… - Nutrients, 2021 - mdpi.com
Whether the gut microbiome in obesity is characterized by lower diversity and altered
composition at the phylum or genus level may be more accurately investigated using high …

Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes.

M Laudes - Journal of molecular endocrinology, 2011 - europepmc.org
The development of obesity is characterised not only by increased storage of lipids in
existing fat cells but also by the generation of new adipocytes from progenitor cells. This …

Large-scale association analyses identify host factors influencing human gut microbiome composition

A Kurilshikov, C Medina-Gomez, R Bacigalupe… - Nature …, 2021 - nature.com
To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

J Wang, LB Thingholm, J Skiecevičienė, P Rausch… - Nature …, 2016 - nature.com
Human gut microbiota is an important determinant for health and disease, and recent
studies emphasize the numerous factors shaping its diversity. Here we performed a genome …

[PDF][PDF] Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition

LB Thingholm, MC Rühlemann, M Koch, B Fuqua… - Cell host & …, 2019 - cell.com
Obesity and type 2 diabetes (T2D) are metabolic disorders that are linked to microbiome
alterations. However, their co-occurrence poses challenges in disentangling microbial …

[HTML][HTML] Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

T Hollstein, DM Schulte, J Schulz, A Glück… - Nature …, 2020 - nature.com
Here we report a case where the manifestations of insulin-dependent diabetes occurred
following SARS-CoV-2 infection in a young individual in the absence of autoantibodies …

[HTML][HTML] Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases

O Schultz, F Oberhauser, J Saech, A Rubbert-Roth… - PloS one, 2010 - journals.plos.org
Background Interleukin-6 (IL-6) is a pro-inflammatory cytokine that has been found to be
increased in type 2 diabetic subjects. However, it still remains unclear if these elevated IL-6 …

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility

A Sazonovs, CR Stevens, GR Venkataraman, K Yuan… - Nature …, 2022 - nature.com
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

[PDF][PDF] Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

R Pryor, P Norvaisas, G Marinos, L Best, LB Thingholm… - Cell, 2019 - cell.com
Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging
drug. We set out to address the fundamental question of how gut microbes and nutrition, key …

Is human obesity an inflammatory disease of the hypothalamus?

L Sonnefeld, N Rohmann, C Geisler… - European Journal of …, 2023 - academic.oup.com
Obesity and its comorbidities are long-standing, challenging global health problems. Lack of
exercise, overnutrition, and especially the consumption of fat-rich foods are some of the most …