Background The purpose of the study was to evaluate whether the mutational status of
Kirsten rat sarcoma viral oncogene homolog (KRAS) or b-viral oncogene homolog B1 …

Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated
with an increased risk for developing breast and ovarian cancers. Current evidence …

The current availability of new Poly (ADP-ribose) Polymerase (PARP)-inhibitors for the
treatment of ovarian cancer patients independently of the presence of a BRCA pathogenic …

How genomic heterogeneity associated with acquired resistance to targeted agents affects
response to subsequent therapy is unknown. We studied EGFR blockade in colorectal …

We sought to develop criteria for ERBB2-positivity (HER2) in colorectal cancer to ensure
accurate identification of ERBB2-amplified metastatic colorectal cancer patients suitable for …

Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer
(NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate …

Abstract Arginase 1 (ARG1) inhibits T‐cell proliferation by degrading extracellular arginine,
which results in decreased responsiveness of T cells to CD3/TCR stimulation. In humans …

Objective Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking
disease relapse in colorectal cancer (CRC). This approach requires personalised assay …

Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating
targeted therapy based on driving somatic alterations. Here we perform transcriptome …

The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum
samples from 5 patients with probable cerebral aspergillosis and from 16 control patients …