User profiles for "author:Mayinuer Maitituoheti"
Mayinuer MaitituohetiHouston Methodist, Weill Cornell Medicine Verified email at houstonmethodist.org Cited by 686 |
[PDF][PDF] KMT2D deficiency impairs super-enhancers to confer a glycolytic vulnerability in lung cancer
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …
[PDF][PDF] Systematic epigenomic analysis reveals chromatin states associated with melanoma progression
The extent and nature of epigenomic changes associated with melanoma progression is
poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications …
poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications …
EMDomics: a robust and powerful method for the identification of genes differentially expressed between heterogeneous classes
Motivation: A major goal of biomedical research is to identify molecular features associated
with a biological or clinical class of interest. Differential expression analysis has long been …
with a biological or clinical class of interest. Differential expression analysis has long been …
[PDF][PDF] Enhancer reprogramming confers dependence on glycolysis and IGF signaling in KMT2D mutant melanoma
Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations
in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor …
in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor …
[HTML][HTML] The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma
SE Lamhamedi-Cherradi, M Maitituoheti… - Nature …, 2022 - nature.com
Desmoplastic small round cell tumor (DSRCT) is an aggressive, usually incurable sarcoma
subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests …
subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests …
[PDF][PDF] Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
The dynamic evolution of chromatin state patterns during metastasis, their relationship with
bona fide genetic drivers, and their therapeutic vulnerabilities are not completely …
bona fide genetic drivers, and their therapeutic vulnerabilities are not completely …
[HTML][HTML] Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
S Adhikary, D Chakravarti, C Terranova… - Nature …, 2019 - nature.com
Abstract The roles of Plant Homeodomain (PHD) fingers in catalysis of histone modifications
are unknown. We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 …
are unknown. We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 …
Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer
Objective Enhancer aberrations are beginning to emerge as a key epigenetic feature of
colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns …
colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns …
An integrated platform for genome-wide mapping of chromatin states using high-throughput ChIP-sequencing in tumor tissues
Histone modifications constitute a major component of the epigenome and play important
regulatory roles in determining the transcriptional status of associated loci. In addition, the …
regulatory roles in determining the transcriptional status of associated loci. In addition, the …
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 …
L Han, W Wang, Y Fang, Z Feng, S Liao… - The Journal of …, 2009 - journals.aai.org
B and T lymphocyte attenuator (BTLA)-herpesvirus entry mediator (HVEM) signaling
coinhibitory pathway is believed to impair antitumor immune competences. An intriguing …
coinhibitory pathway is believed to impair antitumor immune competences. An intriguing …