User profiles for "author:Michael A Newton"

Michael A Newton

Professor of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin
Verified email at wisc.edu
Cited by 18023

Approximate Bayesian inference with the weighted likelihood bootstrap

MA Newton, AE Raftery - Journal of the Royal Statistical Society …, 1994 - academic.oup.com
We introduce the weighted likelihood bootstrap (WLB) as a way to simulate approximately
from a posterior distribution. This method is often easy to implement, requiring only an …

Essential hypertension: renin and aldosterone, heart attack and stroke

HR Brunner, JH Laragh, L Baer… - … England Journal of …, 1972 - Mass Medical Soc
In 219 patients with essential hypertension, aldosterone excretion and plasma renin activity
were related to daily sodium excretion and compared to a nomogram drawn from 52 normal …

On differential variability of expression ratios: improving statistical inference about gene expression changes from microarray data

MA Newton, CM Kendziorski, CS Richmond… - Journal of …, 2001 - liebertpub.com
We consider the problem of inferring fold changes in gene expression from cDNA microarray
data. Standard procedures focus on the ratio of measured fluorescent intensities at each …

Detecting differential gene expression with a semiparametric hierarchical mixture method

MA Newton, A Noueiry, D Sarkar, P Ahlquist - Biostatistics, 2004 - academic.oup.com
Mixture modeling provides an effective approach to the differential expression problem in
microarray data analysis. Methods based on fully parametric mixture models are available …

Bayesian phylogenetic inference via Markov chain Monte Carlo methods

B Mau, MA Newton, B Larget - Biometrics, 1999 - Wiley Online Library
We derive a Markov chain to sample from the posterior distribution for a phylogenetic tree
given sequence information from the corresponding set of organisms, a stochastic model for …

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins

S Sengupta, JA den Boon, IH Chen… - Proceedings of the …, 2008 - National Acad Sciences
Using highly sensitive microarray-based procedures, we identified eight microRNAs
(miRNAs) showing robust differential expression between 31 laser-capture-microdissected …

[HTML][HTML] Drosophila RNAi screen identifies host genes important for influenza virus replication

L Hao, A Sakurai, T Watanabe, E Sorensen, CA Nidom… - Nature, 2008 - nature.com
All viruses rely on host cell proteins and their associated mechanisms to complete the viral
life cycle. Identifying the host molecules that participate in each step of virus replication …

Fundamental differences in cell cycle deregulation in human papillomavirus–positive and human papillomavirus–negative head/neck and cervical cancers

D Pyeon, MA Newton, PF Lambert, JA Den Boon… - Cancer research, 2007 - AACR
Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30%
of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV …

Estimating the integrated likelihood via posterior simulation using the harmonic mean identity

AE Raftery, MA Newton, JM Satagopan, PN Krivitsky - 2006 - biostats.bepress.com
The integrated likelihood (also called the marginal likelihood or the normalizing constant) is
a central quantity in Bayesian model selection and model averaging. It is defined as the …

Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells

SM Taapken, BS Nisler, MA Newton… - Nature …, 2011 - nature.com
To the Editor: Although induced pluripotent stem cells (iPSCs) resemble embryonic stem
cells (ESCs) with regard to pluripotency1, 2, reports of transcriptional, epigenetic and …