Helicobacter pylori is an important human pathogen that colonises the stomach of about half
of the world's population. The bacterium has now been accepted as the causative agent of …

Human studies have firmly implicated voltage-gated sodium channels in human pain
disorders, and targeted and massively parallel genomic sequencing is beginning to be used …

Pain is a frequent debilitating feature reported in peripheral neuropathies with involvement
of small nerve (Aδ and C) fibers. Voltage‐gated sodium channels are responsible for the …

Objective: Small nerve fiber neuropathy (SFN) often occurs without apparent cause, but no
systematic genetic studies have been performed in patients with idiopathic SFN (I‐SFN). We …

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-
function variants of sodium channel Nav1. 7 have recently been found in∼ 30% of cases of …

Background Mouse models have shown that interleukin (IL) 6 stimulates survival,
proliferation and progression to cancer of intestinal epithelial cells via activation of signal …

Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …

Helicobacter pylori isolates show greater genetic diversity than other bacterial species
studied, but the basis for this phenomenon is unknown. Whether detectable genomic …

Most Helicobacter pylori strains are susceptible to tetracycline, an antibiotic commonly used
for the eradication of H. pylori. However, an increase in incidence of tetracycline resistance …

Idiopathic small-fiber neuropathy (I-SFN), clinically characterized by burning pain in distal
extremities and autonomic dysfunction, is a disorder of small-caliber nerve fibers of unknown …