British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
CA Lamb, NA Kennedy, T Raine, PA Hendy, PJ Smith… - Gut, 2019 - gut.bmj.com
Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …
Both represent chronic inflammation of the gastrointestinal tract, which displays …
Response to SARS-CoV-2 vaccination in immune mediated inflammatory diseases: systematic review and meta-analysis
Objectives The treatment for COVID-19 often utilizes immune-modulating drugs. These
drugs are also used in immune mediated inflammatory diseases (IMIDs). We performed a …
drugs are also used in immune mediated inflammatory diseases (IMIDs). We performed a …
Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
[HTML][HTML] Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Background Crohn's disease and ulcerative colitis are the two major forms of inflammatory
bowel disease; treatment strategies have historically been determined by this binary …
bowel disease; treatment strategies have historically been determined by this binary …
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a
lower level of immunity across more of the population. We investigated whether patients with …
lower level of immunity across more of the population. We investigated whether patients with …
[HTML][HTML] COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case …
JL Alexander, NA Kennedy, H Ibraheim… - The lancet …, 2022 - thelancet.com
Background The effects that therapies for inflammatory bowel disease (IBD) have on
immune responses to SARS-CoV-2 vaccination are not yet fully known. Therefore, we …
immune responses to SARS-CoV-2 vaccination are not yet fully known. Therefore, we …
[HTML][HTML] Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
used biologic drugs for treating immune-mediated diseases, but repeated administration can …