Understanding the contribution of family history to colorectal cancer risk and its clinical implications: a state‐of‐the‐science review

JT Lowery, DJ Ahnen, PC Schroy III, H Hampel… - Cancer, 2016 - Wiley Online Library
Persons with a family history (FH) of colorectal cancer (CRC) or adenomas that are not due
to known hereditary syndromes have an increased risk for CRC. An understanding of these …

Hereditary cancer syndromes—A primer on diagnosis and management: Part 1: Breast-ovarian cancer syndromes

NJ Samadder, KV Giridhar, N Baffy… - Mayo Clinic …, 2019 - Elsevier
Cancer is the second leading cause of death in both men and women in the United States,
with colorectal cancer and breast cancer being two of the most frequent cancer types …

Use of family history and genetic testing to determine risk of colorectal cancer

F Kastrinos, NJ Samadder, RW Burt - Gastroenterology, 2020 - Elsevier
Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …

Comparison of universal genetic testing vs guideline-directed targeted testing for patients with hereditary cancer syndrome

NJ Samadder, D Riegert-Johnson, L Boardman… - JAMA …, 2021 - jamanetwork.com
Importance Hereditary factors play a key role in the risk of developing several cancers.
Identification of a germline predisposition can have important implications for treatment …

Characteristics of missed or interval colorectal cancer and patient survival: a population-based study

NJ Samadder, K Curtin, TMF Tuohy, L Pappas… - Gastroenterology, 2014 - Elsevier
Background & Aims Colorectal cancers (CRCs) diagnosed within a few years after an index
colonoscopy can arise from missed lesions or the development of a new tumor. We …

Effect of sulindac and erlotinib vs placebo on duodenal neoplasia in familial adenomatous polyposis: a randomized clinical trial

NJ Samadder, DW Neklason, KM Boucher, KR Byrne… - Jama, 2016 - jamanetwork.com
Importance Patients with familial adenomatous polyposis (FAP) are at markedly increased
risk for duodenal polyps and cancer. Surgical and endoscopic management of duodenal …

Cancer risk in families fulfilling the Amsterdam criteria for Lynch syndrome

NJ Samadder, KR Smith, J Wong, A Thomas… - JAMA …, 2017 - jamanetwork.com
Importance The data describing cancer risks associated with Lynch syndrome are variable.
Objectives To quantify the prevalence of families that fulfill the Amsterdam I or II criteria for …

Risk of colorectal cancer and adenomas in the families of patients with adenomas: A population‐based study in Utah

TMF Tuohy, KG Rowe, GP Mineau, R Pimentel… - Cancer, 2014 - Wiley Online Library
BACKGROUND Guidelines recommend that individuals with a first‐degree relative (FDR)
diagnosed with colorectal cancer (CRC) or advanced adenoma before age 60 years should …

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in familial adenomatous polyposis syndromes

J Yang, SR Gurudu, C Koptiuch, D Agrawal… - Gastrointestinal …, 2020 - Elsevier
Familial adenomatous polyposis (FAP) syndrome is a complex entity, which includes FAP,
attenuated FAP, and MUTYH-associated polyposis. These patients are at significant risk for …

Family history associates with increased risk of colorectal cancer in patients with inflammatory bowel diseases

NJ Samadder, JF Valentine, S Guthery, H Singh… - Clinical …, 2019 - Elsevier
Background & Aims Individuals with inflammatory bowel diseases (IBDs) have an increased
risk of developing colorectal cancer (CRC). Although family history of CRC is a well …