[HTML][HTML] Are animal models predictive for humans?

N Shanks, R Greek, J Greek - Philosophy, ethics, and humanities in …, 2009 - Springer
It is one of the central aims of the philosophy of science to elucidate the meanings of
scientific terms and also to think critically about their application. The focus of this essay is …

Peripartum plasticity within the hypothalamo-pituitary-adrenal axis

…, RJ Windle, SA Wood, YM Kershaw, N Shanks… - Progress in brain …, 2001 - Elsevier
The hypothalamo-pituitary-adrenal (HPA) axis plays important roles in the adaptive changes
in physiology that occur during pregnancy and lactation. Although the axis still exhibits a …

Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response

…, S Larocque, D Francis, D O'Donnell, N Shanks… - Cellular and molecular …, 1993 - Springer
Several years ago, investigators described the effects of infantile handling on the
development of hypothalamic-pituitary-adrenal (HPA) responses to stress in the rat. Rat …

Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats

RJ Windle, N Shanks, SL Lightman, CD Ingram - Endocrinology, 1997 - academic.oup.com
Endocrine responses to noise stress and anxiety-related behaviors were measured in
groups of ovariectomized, estradiol-treated female rats given central infusions of oxytocin …

Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination

K Vedhara, NKM Cox, GK Wilcock, P Perks, M Hunt… - The Lancet, 1999 - thelancet.com
Background There are many reports of psychological morbidity in spousal carers of patients
with dementia. The consequences of this increased stress on the immune system are …

Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo–pituitary–adrenal activity

RJ Windle, YM Kershaw, N Shanks… - Journal of …, 2004 - Soc Neuroscience
We reported previously that the neuropeptide oxytocin attenuates stress-induced
hypothalamo–pituitary–adrenal (HPA) activity and anxiety behavior. This study sought to …

Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress

RJ Windle, SA Wood, N Shanks, SL Lightman… - …, 1998 - academic.oup.com
The present study investigated the dynamic regulation of the hypothalamo-pituitary-adrenal
axis and its significance to acute stress responsiveness in the female rat. An automated …

Early-life exposure to endotoxin alters hypothalamic–pituitary–adrenal function and predisposition to inflammation

N Shanks, RJ Windle, PA Perks… - Proceedings of the …, 2000 - National Acad Sciences
We have investigated whether exposure to Gram-negative bacterial endotoxin in early
neonatal life can alter neuroendocrine and immune regulation in adult animals. Exposure of …

Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids

…, P Perks, GK Wilcock, SL Lightman, N Shanks - Journal of …, 2000 - Elsevier
Caring for the chronically ill is associated with chronic distress. In view of the adverse effects
of distress on cellular immune function, such distress may have implications for health …

Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress

N Shanks, S Larocque, MJ Meaney - Journal of Neuroscience, 1995 - Soc Neuroscience
The long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-
adrenal axis (HPA) function were assessed in adult female and male Long-Evans rats. At 3 …