Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

S Baumgart, NM Chen, JT Siveke, A König, JS Zhang… - Cancer discovery, 2014 - AACR
Cancer-associated inflammation is a molecular key feature in pancreatic ductal
adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to …

Antithetical NFAT c1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity

SK Singh, NM Chen, E Hessmann, J Siveke… - The EMBO …, 2015 - embopress.org
In adaptation to oncogenic signals, pancreatic ductal adenocarcinoma (PDAC) cells
undergo epithelial–mesenchymal transition (EMT), a process combining tumor cell …

The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically …

V Fendrich, NM Chen, M Neef, J Waldmann… - Gut, 2010 - gut.bmj.com
Background and aims There are no chemopreventive strategies for pancreatic cancer or its
precursor lesions, pancreatic intraepithelial neoplasia (PanINs). Recent evidence suggests …

NFATc1 links EGFR signaling to induction of Sox9 transcription and acinar–ductal transdifferentiation in the pancreas

NM Chen, G Singh, A Koenig, GY Liou, P Storz… - Gastroenterology, 2015 - Elsevier
Background & Aims Oncogenic mutations in KRAS contribute to the development of
pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis …

Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer

S Baumgart, E Glesel, G Singh, NM Chen, K Reutlinger… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Transcriptional silencing of the p15INK4b tumor suppressor
pathway overcomes cellular protection against unrestrained proliferation in cancer. Here we …

[HTML][HTML] Context-dependent epigenetic regulation of nuclear factor of activated T cells 1 in pancreatic plasticity

NM Chen, A Neesse, ML Dyck, B Steuber, AO Koenig… - Gastroenterology, 2017 - Elsevier
Background & Aims The ability of exocrine pancreatic cells to change the cellular phenotype
is required for tissue regeneration upon injury, but also contributes to their malignant …

GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression

S Baumgart, NM Chen, JS Zhang, DD Billadeau… - Molecular cancer …, 2016 - AACR
We aimed to investigate the mechanistic, functional, and therapeutic role of glycogen
synthase kinase 3β (GSK-3β) in the regulation and activation of the proinflammatory …

[HTML][HTML] NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

E Hessmann, JS Zhang, NM Chen… - Stem cells …, 2016 - hindawi.com
Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of
acinar cells to external stress signals and is considered to be the initial step in pancreatic …

[HTML][HTML] The impact of disclosing emotions on ratings of interpersonal closeness, warmth, competence, and leadership ability

VU Ludwig, B Berry, JY Cai, NM Chen… - Frontiers in …, 2022 - frontiersin.org
Introduction Increasingly, business leaders and other professionals are called upon to be
vulnerable and authentic in the workplace, which often includes disclosing emotions to …

Analysis of codon bias of chloroplast genome in Eucalyptus grandis.

P Wang, S Wu, L Yang, H Wang, N Chen, Z Zhang - 2019 - cabidigitallibrary.org
In this study, analysis of codon bias was carried out using CodonW 1.4. 2 software, with
chloroplast genome of Eucalyptus grandis as material and 43 non-repeated genes …