Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D
Cancer-associated inflammation is a molecular key feature in pancreatic ductal
adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to …
adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to …
Antithetical NFAT c1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity
In adaptation to oncogenic signals, pancreatic ductal adenocarcinoma (PDAC) cells
undergo epithelial–mesenchymal transition (EMT), a process combining tumor cell …
undergo epithelial–mesenchymal transition (EMT), a process combining tumor cell …
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically …
V Fendrich, NM Chen, M Neef, J Waldmann… - Gut, 2010 - gut.bmj.com
Background and aims There are no chemopreventive strategies for pancreatic cancer or its
precursor lesions, pancreatic intraepithelial neoplasia (PanINs). Recent evidence suggests …
precursor lesions, pancreatic intraepithelial neoplasia (PanINs). Recent evidence suggests …
NFATc1 links EGFR signaling to induction of Sox9 transcription and acinar–ductal transdifferentiation in the pancreas
NM Chen, G Singh, A Koenig, GY Liou, P Storz… - Gastroenterology, 2015 - Elsevier
Background & Aims Oncogenic mutations in KRAS contribute to the development of
pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis …
pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis …
Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer
S Baumgart, E Glesel, G Singh, NM Chen, K Reutlinger… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Transcriptional silencing of the p15INK4b tumor suppressor
pathway overcomes cellular protection against unrestrained proliferation in cancer. Here we …
pathway overcomes cellular protection against unrestrained proliferation in cancer. Here we …
[HTML][HTML] Context-dependent epigenetic regulation of nuclear factor of activated T cells 1 in pancreatic plasticity
NM Chen, A Neesse, ML Dyck, B Steuber, AO Koenig… - Gastroenterology, 2017 - Elsevier
Background & Aims The ability of exocrine pancreatic cells to change the cellular phenotype
is required for tissue regeneration upon injury, but also contributes to their malignant …
is required for tissue regeneration upon injury, but also contributes to their malignant …
GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression
S Baumgart, NM Chen, JS Zhang, DD Billadeau… - Molecular cancer …, 2016 - AACR
We aimed to investigate the mechanistic, functional, and therapeutic role of glycogen
synthase kinase 3β (GSK-3β) in the regulation and activation of the proinflammatory …
synthase kinase 3β (GSK-3β) in the regulation and activation of the proinflammatory …
[HTML][HTML] NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation
E Hessmann, JS Zhang, NM Chen… - Stem cells …, 2016 - hindawi.com
Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of
acinar cells to external stress signals and is considered to be the initial step in pancreatic …
acinar cells to external stress signals and is considered to be the initial step in pancreatic …
[HTML][HTML] The impact of disclosing emotions on ratings of interpersonal closeness, warmth, competence, and leadership ability
Introduction Increasingly, business leaders and other professionals are called upon to be
vulnerable and authentic in the workplace, which often includes disclosing emotions to …
vulnerable and authentic in the workplace, which often includes disclosing emotions to …
Analysis of codon bias of chloroplast genome in Eucalyptus grandis.
P Wang, S Wu, L Yang, H Wang, N Chen, Z Zhang - 2019 - cabidigitallibrary.org
In this study, analysis of codon bias was carried out using CodonW 1.4. 2 software, with
chloroplast genome of Eucalyptus grandis as material and 43 non-repeated genes …
chloroplast genome of Eucalyptus grandis as material and 43 non-repeated genes …