The review synthesised evidence examining the association between a. loneliness with
inflammation and b. social isolation with inflammation in adults aged 16 or older from the …

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation
of highly differentiated CD45RA re-expressing memory T cells. These cells increase during …

Antiretroviral therapy has significantly reduced morbidity and mortality in people living with
HIV (PLWH). However, a direct consequence of higher survival is the development of ageing …

Objective To investigate the underlying mechanisms behind changes in glucose
homeostasis with delivery of propionate to the human colon by comprehensive and …

T cell senescence is thought to contribute to immune function decline, but the pathways that
mediate senescence in these cells are not clear. Here, we evaluated T cell populations from …

An acute bout of exercise evokes mobilisation of lymphocytes into the bloodstream, which
can be largely attributed to increases in CD8+ T lymphocytes (CD8TLs) and natural killer …

Persistent viral infections and inflammatory syndromes induce the accumulation of T cells
with characteristics of terminal differentiation or senescence. However, the mechanism that …

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the
immune system, is characterized by impaired protective immunity and decreased efficacy of …

Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …

Immune enhancement is desirable in situations where decreased immunity results in
increased morbidity. We investigated whether blocking the surface inhibitory receptor PD‐1 …