Consensus guidelines for the detection of immunogenic cell death

O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma

M Erkan, CW Michalski, S Rieder… - Clinical …, 2008 - Elsevier
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly
desmoplastic tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) …

The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells

GA Salg, NA Giese, M Schenk… - Journal of tissue …, 2019 - journals.sagepub.com
A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …

Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity

B Madhavan, S Yue, U Galli, S Rana… - … journal of cancer, 2015 - Wiley Online Library
Late diagnosis contributes to pancreatic cancer (PaCa) dismal prognosis, urging for reliable,
early detection. Serum‐exosome protein and/or miRNA markers might be suitable …

Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity

M Erkan, J Kleeff, A Gorbachevski, C Reiser, T Mitkus… - Gastroenterology, 2007 - Elsevier
Background & Aims: Pancreatic cancer creates desmoplasia by stimulating stellate cells
(PSCs), thereby influencing tumor aggressiveness. The aim of this study was to analyze the …

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

BM Wolpin, C Rizzato, P Kraft, C Kooperberg… - Nature …, 2014 - nature.com
We performed a multistage genome-wide association study including 7,683 individuals with
pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome …

Pancreatic neuropathy and neuropathic pain—a comprehensive pathomorphological study of 546 cases

GO Ceyhan, F Bergmann, M Kadihasanoglu, B Altintas… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Chronic pancreatitis (CP) and pancreatic adenocarcinoma (PCa)
are characterized by intrapancreatic neural alterations and pain. Our aims were to:(a) …

Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8

T Walle, JA Kraske, B Liao, B Lenoir, C Timke… - Science …, 2022 - science.org
Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T
cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains …

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

EM Noll, C Eisen, A Stenzinger, E Espinet… - Nature medicine, 2016 - nature.com
Although subtypes of pancreatic ductal adenocarcinoma (PDAC) have been described, this
malignancy is clinically still treated as a single disease. Here we present patient-derived …

NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer

C Heining, P Horak, S Uhrig, PL Codo, B Klink, B Hutter… - Cancer discovery, 2018 - AACR
We used whole-genome and transcriptome sequencing to identify clinically actionable
genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC) …