Introduction Superior mesenteric artery (SMA) syndrome is an unusual cause of vomiting
and weight loss resulting from the compression of the third part of the duodenum by the …

With the availability of a therapeutic target and an effective agent in trastuzumab, a
systematic examination of the literature to investigate the role of human epidermal growth …

Background R0 resection rates (complete tumour removal with negative resection margins)
in pancreatic cancer are 70–80 per cent when a 0-mm margin is used, declining to 15–24 …

Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Purpose Current adjuvant therapies for pancreatic cancer (PC) are inconsistently used and
only modestly effective. Because a high proportion of patients who undergo resection for PC …

Background Current staging methods for pancreatic cancer (PC) are inadequate, and
biomarkers to aid clinical decision making are lacking. Despite the availability of the serum …

Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation
burden and defective DNA repair are associated with response to immune checkpoint …