Cancer genome landscapes
Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …
landscapes of common forms of human cancer. For most cancer types, this landscape …
The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?
Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best
hope for a cure, but characteristics of this disease, such as the lack of early clinical …
hope for a cure, but characteristics of this disease, such as the lack of early clinical …
Molecular basis of HNPCC: mutations of MMR genes
N Papadopoulos, A Lindblom - Human mutation, 1997 - Wiley Online Library
Hereditary nonpolyposis colorectal cancer (HNPCC) is inherited as a dominant disorder
caused by germline defects in one of at least four mismatch repair (MMR) genes. Two of …
caused by germline defects in one of at least four mismatch repair (MMR) genes. Two of …
[HTML][HTML] PD-1 blockade in tumors with mismatch-repair deficiency
Background Somatic mutations have the potential to encode “non-self” immunogenic
antigens. We hypothesized that tumors with a large number of somatic mutations due to …
antigens. We hypothesized that tumors with a large number of somatic mutations due to …
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of
somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers …
somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers …
Detection of circulating tumor DNA in early-and late-stage human malignancies
C Bettegowda, M Sausen, RJ Leary, I Kinde… - Science translational …, 2014 - science.org
The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based …
major challenge in oncology. We used digital polymerase chain reaction–based …
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
S Jones, X Zhang, DW Parsons, JCH Lin, RJ Leary… - science, 2008 - science.org
There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …
The consensus coding sequences of human breast and colorectal cancers
The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …
The genomic landscapes of human breast and colorectal cancers
Human cancer is caused by the accumulation of mutations in oncogenes and tumor
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we …
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we …
[HTML][HTML] Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
FS Leach, NC Nicolaides, N Papadopoulos, B Liu… - Cell, 1993 - cell.com
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …