User profiles for "author:P Howell"

P. Lynne Howell

- Verified email at sickkids.ca - Cited by 12809

Peter Howell

- Verified email at ucl.ac.uk - Cited by 10760

[HTML][HTML] Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

MJ Franklin, DE Nivens, JT Weadge… - Frontiers in …, 2011 - frontiersin.org
Pseudomonas aeruginosa thrives in many aqueous environments and is an opportunistic
pathogen that can cause both acute and chronic infections. Environmental conditions and …

The good, the bad, and the tiny: a review of microflow cytometry

DA Ateya, JS Erickson, PB Howell, LR Hilliard… - Analytical and …, 2008 - Springer
Recent developments in microflow cytometry have concentrated on advancing technology in
four main areas:(1) focusing the particles to be analyzed in the microfluidic channel,(2) …

Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria

JC Whitney, PL Howell - Trends in microbiology, 2013 - cell.com
The biosynthesis and export of bacterial cell-surface polysaccharides is known to occur
through several distinct mechanisms. Recent advances in the biochemistry and structural …

[HTML][HTML] Bedaquiline–pretomanid–linezolid regimens for drug-resistant tuberculosis

…, TR Bagdasaryan, S Borisov, P Howell… - … England Journal of …, 2022 - Mass Medical Soc
Background The bedaquiline–pretomanid–linezolid regimen has been reported to have
90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events …

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

LK Jennings, KM Storek, HE Ledvina… - Proceedings of the …, 2015 - National Acad Sciences
Biofilm formation is a complex, ordered process. In the opportunistic pathogen
Pseudomonas aeruginosa, Psl and Pel exopolysaccharides and extracellular DNA (eDNA) …

Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov… - Science, 2015 - science.org
INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity

D Nehra, P Howell, CP Williams, JK Pye, J Beynon - Gut, 1999 - gut.bmj.com
BACKGROUND Bile acid toxicity has been shown in the gastric, colonic, and hepatic
tissues; the effect on oesophageal mucosa is less well known. AIMS To determine the …

The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix

KM Colvin, Y Irie, CS Tart, R Urbano… - Environmental …, 2012 - Wiley Online Library
Extracellular polysaccharides comprise a major component of the biofilm matrix. Many
species that are adept at biofilm formation have the capacity to produce multiple types of …

[HTML][HTML] Treatment of highly drug-resistant pulmonary tuberculosis

…, AH Diacon, N Ngubane, P Howell… - … England Journal of …, 2020 - Mass Medical Soc
Background Patients with highly drug-resistant forms of tuberculosis have limited treatment
options and historically have had poor outcomes. Methods In an open-label, single-group …

The nature of acicular ferrite in HSLA steel weld metals

RA Ricks, PR Howell, GS Barritte - Journal of materials science, 1982 - Springer
In this paper, the nature of the fine interlocking acicular ferrite microstructure in HSLA steel
weld metals is investigated. The results strongly suggest the acicular ferrite is comprised of …