Dogs play an important role in toxicology because of their importance as a large animal, pre-
clinical model for evaluating potential toxicity in human drug development including the …

Autoimmune associated bone disease and intestinal inflammation are closely linked with
deregulation and hyperactivation of autoreactive CD4 T cells. How these T cells are …

Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the
common gamma chain (γc) gene and is identical clinically and immunologically to human …

Eighteen young Beagle dogs (eight males and 10 females), ages 6-40 months, with canine
juvenile polyarteritis syndrome (CJPS), a naturally occurring vasculitis and perivasculitis of …

The interleukin-2-deficient (IL-2−/−) mouse model of ulcerative colitis was used to test the
hypothesis that colonic epithelial cells (CEC) directly respond to bacterial antigens and that …

A systemic necrotizing vasculitis of unknown etiopathogenesis may be termed juvenile
polyarteritis syndrome (jps). The syndrome has been recognized primarily in young Beagles …

Background and aims: As the first point of contact with enteric antigens, intestinal epithelial
cells (IEC) may be key in regulating mucosal immune responses. We determined therefore if …

AIM: To determine if primary murine colonic epithelial cells (CEC) respond to commensal
bacteria and discriminate between different types of bacteria. METHODS: A novel CEC …

This study describes the immunologic abnormalities during the acute phase of juvenile
polyarteritis syndrome (JPS), a multisystem necrotizing vasculitis of young dogs with a …

X-linked severe combined immunodeficiency (SCID) is characterized by profound defects in
cellular and humoral immunity and, in humans, is associated with mutations in the gene for …