The demands that are imposed on the liver as a result of its function as a metabolic organ
that extracts nutrients and clears gut-derived microbial products from the blood are met by a …

The physiological function of the liver–such as removal of pathogens and antigens from the
blood, protein synthesis and metabolism–requires an immune response that is adapted to …

The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

Hepatocellular carcinoma (HCC) can have viral or non-viral causes,,,–. Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …

Infection-neutralizing antibody responses after severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an …

Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …

Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on
major histocompatibility class I molecules to CD8+ T cells and thereby induce protective …

Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …

Liver fibrosis is orchestrated by a complex network of signaling pathways regulating the
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …

The mechanisms that allow antigen-presenting cells (APCs) to selectively present
extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells …