Breast cancer (BC) is the most common malignancy and the second cause of cancer-
specific death in women from high-income countries. Recently, gut microbiota dysbiosis …

Background & Aims Stenosis is a common complication of Crohn's disease (CD) that has no
effective medical therapy. Development of antifibrotic agents will require testing in …

Hepatocyte cell death, inflammation and oxidative stress constitute key pathogenic
mechanisms underlying non-alcoholic fatty liver disease (NAFLD). We aimed to investigate …

Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and
clinical remission. However, there is active discussion about the additional advantages of …

This new diagnostic consensus guideline is a joint project of the European Crohn's and
Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal …

Abstract Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas.
Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation …

Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent
need to promptly direct non-responder patients to alternative therapies. Infiltrating T …

In inflammatory bowel disease [IBD], mucosal healing is a major therapeutic target and a
reliable predictor of clinical course. However, endoscopic mucosal healing is not …

Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability
pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor …

Objective Effective medical therapy and validated trial outcomes are lacking for small bowel
Crohn's disease (CD) strictures. Histopathology of surgically resected specimens is the gold …