Mitochondrial reactive oxygen species and Ca2+ signaling

C Camello-Almaraz, PJ Gomez-Pinilla… - … of Physiology-Cell …, 2006 - journals.physiology.org
Mitochondria are an important source of reactive oxygen species (ROS) formed as a side
product of oxidative phosphorylation. The main sites of oxidant production are complex I and …

New therapeutic strategies for postoperative ileus

SHW Van Bree, A Nemethova, C Cailotto… - Nature reviews …, 2012 - nature.com
Patients undergoing an abdominal surgical procedure develop a transient episode of
impaired gastrointestinal motility or postoperative ileus. Importantly, postoperative ileus is a …

Postoperative ileus: pathophysiology, current therapeutic approaches

N Stakenborg, PJ Gomez-Pinilla… - Gastrointestinal …, 2017 - Springer
Postoperative ileus, which develops after each abdominal surgical procedure, is an
iatrogenic disorder characterized by a transient inhibition of gastrointestinal motility. Its …

Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract

PJ Gomez-Pinilla, SJ Gibbons… - American Journal …, 2009 - journals.physiology.org
Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal
neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit …

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

G Matteoli, PJ Gomez-Pinilla, A Nemethova… - Gut, 2014 - gut.bmj.com
The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism
by which the brain, through the vagus nerve, modulates the immune system in the spleen …

Effect of age on the enteric nervous system of the human colon

CE Bernard, SJ Gibbons… - …, 2009 - Wiley Online Library
The effect of age on the anatomy and function of the human colon is incompletely
understood. The prevalence of disorders in adults such as constipation increase with age …

Changes in interstitial cells of cajal with age in the human stomach and colon

PJ Gomez‐Pinilla, SJ Gibbons, MG Sarr… - …, 2011 - Wiley Online Library
Background Aging produces inevitable changes in the function of most organs including the
gastrointestinal tract. Together with enteric nerves and smooth muscle cells, interstitial cells …

[HTML][HTML] Neuro-anatomical evidence indicating indirect modulation of macrophages by vagal efferents in the intestine but not in the spleen

C Cailotto, PJ Gomez-Pinilla, LM Costes… - PloS one, 2014 - journals.plos.org
Background Electrical stimulation of the vagus nerve suppresses intestinal inflammation and
normalizes gut motility in a mouse model of postoperative ileus. The exact anatomical …

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

G Farro, M Stakenborg, PJ Gomez-Pinilla, E Labeeuw… - Gut, 2017 - gut.bmj.com
Objective Postoperative ileus (POI) is assumed to result from myeloid cells infiltrating the
intestinal muscularis externa (ME) in patients undergoing abdominal surgery. In the current …

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric …

N Stakenborg, E Labeeuw, PJ Gomez-Pinilla… - Gut, 2019 - gut.bmj.com
Objectives Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents
postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) …