User profiles for "author:Peer Bork"

Peer Bork

Director of EMBL Heidelberg
Verified email at embl.de
Cited by 376152

[HTML][HTML] Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

RM Bowers, NC Kyrpides, R Stepanauskas… - Nature …, 2017 - nature.com
We present two standards developed by the Genomic Standards Consortium (GSC) for
reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum …

Conservation of gene order: a fingerprint of proteins that physically interact

T Dandekar, B Snel, M Huynen, P Bork - Trends in biochemical sciences, 1998 - cell.com
A systematic comparison of nine bacterial and archaeal genomes reveals a low level of
gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs …

Powers and pitfalls in sequence analysis: the 70% hurdle

P Bork - Genome research, 2000 - genome.cshlp.org
High-throughput technologies impress us almost every week with novel global results and
big numbers. They often reveal important general trends that are impossible to realize with …

Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation

I Letunic, P Bork - Nucleic acids research, 2021 - academic.oup.com
Abstract The Interactive Tree Of Life (https://itol. embl. de) is an online tool for the display,
manipulation and annotation of phylogenetic and other trees. It is freely available and open …

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

D Szklarczyk, AL Gable, KC Nastou, D Lyon… - Nucleic acids …, 2021 - academic.oup.com
Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

D Szklarczyk, AL Gable, D Lyon, A Junge… - Nucleic acids …, 2019 - academic.oup.com
Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

STRING v10: protein–protein interaction networks, integrated over the tree of life

D Szklarczyk, A Franceschini, S Wyder… - Nucleic acids …, 2015 - academic.oup.com
The many functional partnerships and interactions that occur between proteins are at the
core of cellular processing and their systematic characterization helps to provide context in …

Enterotypes of the human gut microbiome

M Arumugam, J Raes, E Pelletier, D Le Paslier… - nature, 2011 - nature.com
Our knowledge of species and functional composition of the human gut microbiome is
rapidly increasing, but it is still based on very few cohorts and little is known about variation …

The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest

D Szklarczyk, R Kirsch, M Koutrouli… - Nucleic acids …, 2023 - academic.oup.com
Much of the complexity within cells arises from functional and regulatory interactions among
proteins. The core of these interactions is increasingly known, but novel interactions …

[HTML][HTML] A human gut microbial gene catalogue established by metagenomic sequencing

J Qin, R Li, J Raes, M Arumugam, KS Burgdorf… - nature, 2010 - nature.com
To understand the impact of gut microbes on human health and well-being it is crucial to
assess their genetic potential. Here we describe the Illumina-based metagenomic …