Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …

Importance Leisure-time physical activity has been associated with lower risk of heart-
disease and all-cause mortality, but its association with risk of cancer is not well understood …

Importance The 2008 Physical Activity Guidelines for Americans recommended a minimum
of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5 metabolic …

OBJECTIVE: Obesity and diabetes are associated with an increased liver cancer risk.
However, most studies have examined all primary liver cancers or hepatocellular carcinoma …

The obesity epidemic is attributed in part to reduced physical activity. Evidence supports that
reducing time spent sitting, regardless of activity, may improve the metabolic consequences …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Background Waist circumference (WC), a measure of abdominal obesity, is associated with
higher mortality independent of body mass index (BMI). Less is known about the association …

Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …

OBJECTIVE Diabetes is a major predictor of death from heart disease and stroke; its impact
on nonvascular mortality, including specific cancers, is less understood. We examined the …