[HTML][HTML] Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
S Müller, S Raulefs, P Bruns, F Afonso-Grunz… - Molecular cancer, 2015 - Springer
Background Previous studies identified microRNAs (miRNAs) and messenger RNAs with
significantly different expression between normal pancreas and pancreatic cancer (PDAC) …
significantly different expression between normal pancreas and pancreatic cancer (PDAC) …
[HTML][HTML] MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
The circadian clock and the cell cycle are major cellular systems that organize global
physiology in temporal fashion. It seems conceivable that the potentially conflicting …
physiology in temporal fashion. It seems conceivable that the potentially conflicting …
[HTML][HTML] Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
D Hübschmann, K Kleinheinz, R Wagener… - Leukemia, 2021 - nature.com
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V
(D) J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR) …
(D) J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR) …
[HTML][HTML] A novel NHE1-centered signaling cassette drives epidermal growth factor receptor–dependent pancreatic tumor metastasis and is a target for combination …
RA Cardone, MR Greco, K Zeeberg, A Zaccagnino… - Neoplasia, 2015 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers principally
because of early invasion and metastasis. The epidermal growth factor receptor (EGFR) is …
because of early invasion and metastasis. The epidermal growth factor receptor (EGFR) is …
A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling
B Kong, W Wu, T Cheng, AM Schlitter, C Qian, P Bruns… - Gut, 2016 - gut.bmj.com
Objective Oncogenic Kras-activated robust Mek/Erk signals phosphorylate to the tuberous
sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) …
sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) …
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy
B Kong, P Bruns, NA Behler, L Chang, AM Schlitter… - Gut, 2018 - gut.bmj.com
Objective The initial steps of pancreatic regeneration versus carcinogenesis are
insufficiently understood. Although a combination of oncogenic Kras and inflammation has …
insufficiently understood. Although a combination of oncogenic Kras and inflammation has …
Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis
Background and aims Besides well-defined genetic alterations, the dedifferentiation of
mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar …
mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar …
[HTML][HTML] Glycemic variability promotes both local invasion and metastatic colonization by pancreatic ductal adenocarcinoma
Background & Aims Although nearly half of pancreatic ductal adenocarcinoma (PDAC)
patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment …
patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment …
An ensemble approach for inferring semi-quantitative regulatory dynamics for the differentiation of mouse embryonic stem cells using prior knowledge
The process of differentiation of embryonic stem cells (ESCs) is currently becoming the focus
of many systems biologists not only due to mechanistic interest but also since it is expected …
of many systems biologists not only due to mechanistic interest but also since it is expected …
[HTML][HTML] Metabolism gene signatures and surgical site infections in abdominal surgery
B Kong, P Bruns, S Raulefs, S Rieder, L Paul… - International Journal of …, 2015 - Elsevier
Introduction Surgical site infections (SSI) represent a significant cause of morbidity in
abdominal surgery. The objective of this study was to determine the gene expression …
abdominal surgery. The objective of this study was to determine the gene expression …