User profiles for "author:Phillip A Engen"

Phillip A. Engen, MS

Laboratory Research Supervisor, Rush University Medical Center
Verified email at rush.edu
Cited by 10642

[HTML][HTML] The gastrointestinal microbiome: alcohol effects on the composition of intestinal microbiota

PA Engen, SJ Green, RM Voigt, CB Forsyth… - Alcohol research …, 2015 - ncbi.nlm.nih.gov
The excessive use of alcohol is a global problem causing many adverse pathological health
effects and a significant financial health care burden. This review addresses the effect of …

[HTML][HTML] Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's …

HB Dodiya, CB Forsyth, RM Voigt, PA Engen… - Neurobiology of …, 2020 - Elsevier
Recent evidence provides support for involvement of the microbiota-gut-brain axis in
Parkinson's disease (PD) pathogenesis. We propose that a pro-inflammatory intestinal …

[HTML][HTML] Diet in Parkinson's disease: critical role for the microbiome

A Jackson, CB Forsyth, M Shaikh, RM Voigt… - Frontiers in …, 2019 - frontiersin.org
Background: Parkinson's disease (PD) is the most common movement disorder affecting up
to 1% of the population above the age of 60 and 4–5% of those above the age of 85. Little …

Colonic bacterial composition in Parkinson's disease

A Keshavarzian, SJ Green, PA Engen… - Movement …, 2015 - Wiley Online Library
Abstract Introduction We showed that Parkinson's disease (PD) patients have alpha‐
synuclein (α‐Syn) aggregation in their colon with evidence of colonic inflammation. If PD …

Colonic microbiome is altered in alcoholism

EA Mutlu, PM Gillevet, H Rangwala… - American Journal …, 2012 - journals.physiology.org
Several studies indicate the importance of colonic microbiota in metabolic and inflammatory
disorders and importance of diet on microbiota composition. The effects of alcohol, one of …

Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice

P Perez-Pardo, HB Dodiya, PA Engen, CB Forsyth… - Gut, 2019 - gut.bmj.com
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain
disorders has opened up new directions to explore the possible role of the gut-brain axis in …

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome

EA Mutlu, IY Comba, T Cho, PA Engen, C Yazıcı… - Environmental …, 2018 - Elsevier
Recent studies suggest an association between particulate matter (PM) air pollution and
gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited …

[HTML][HTML] Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice

EA Mutlu, PA Engen, S Soberanes, D Urich… - Particle and fibre …, 2011 - Springer
Background Exposure to particulate matter (PM) air pollution may be an important
environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM …

[HTML][HTML] Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis

F Bishehsari, PA Engen, NZ Preite, YE Tuncil, A Naqib… - Genes, 2018 - mdpi.com
Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC).
One possible mechanism of fiber is its fermentation property in the gut and ability to change …

[HTML][HTML] Lower neighborhood socioeconomic status associated with reduced diversity of the colonic microbiota in healthy adults

GE Miller, PA Engen, PM Gillevet, M Shaikh… - PLoS …, 2016 - journals.plos.org
In the United States, there are persistent and widening socioeconomic gaps in morbidity and
mortality from chronic diseases. Although most disparities research focuses on person-level …