Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels
in the enterohepatic circulation of some individuals and may contribute to the pathogenesis …

The host and microbiome appear to regulate bile acid pool size. The host produces a large,
conjugated hydrophilic bile acid pool, maintained through positive-feedback antagonism of …

Emerging evidence strongly suggest that the human “microbiome” plays an important role in
both health and disease. Bile acids function both as detergents molecules promoting …

Background & Aims The gut microbiome is altered in cirrhosis; however its evolution with
disease progression is only partly understood. We aimed to study changes in the …

BACKGROUND & AIMS: The 7α-dehydroxylation of primary bile acids (BAs),
chenodeoxycholic (CDCA) and cholic acid (CA) into the secondary BAs, lithocholic (LCA) …

In the past, bile acids were considered to be just detergent molecules derived from
cholesterol in the liver. They were known to be important for the solubilization of cholesterol …

Although hepatic encephalopathy (HE) is linked to the gut microbiota, stool microbiome
analysis has not found differences between HE and no-HE patients. This study aimed to …

Hepatic encephalopathy (HE) has been related to gut bacteria and inflammation in the
setting of intestinal barrier dysfunction. We aimed to link the gut microbiome with cognition …

Hepatic encephalopathy (HE) represents a dysfunctional gut-liver-brain axis in cirrhosis
which can negatively impact outcomes. This altered gut-brain relationship has been treated …

Background Safety of individual probiotic strains approved under Investigational New Drug
(IND) policies in cirrhosis with minimal hepatic encephalopathy (MHE) is not clear. Aim The …