Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic …
M Gonzalez-Aparicio, P Alzuguren, I Mauleon… - Gut, 2011 - gut.bmj.com
Background and aims New options are needed for the management and prevention of
colorectal cancer liver metastases. Interleukin 12 (IL-12) is an immunostimulatory cytokine …
colorectal cancer liver metastases. Interleukin 12 (IL-12) is an immunostimulatory cytokine …
Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats
BACKGROUND & AIMS:: Cardiotrophin-1 (CT-1) is a member of the interleukin 6 (IL-6)
family of cytokines, which protect cardiac myocytes against thermal and ischemic insults. In …
family of cytokines, which protect cardiac myocytes against thermal and ischemic insults. In …
[HTML][HTML] Evaluation of bioluminescent imaging for noninvasive monitoring of colorectal cancer progression in the liver and its response to immunogene therapy
M Zabala, P Alzuguren, C Benavides, J Crettaz… - Molecular cancer, 2009 - Springer
Background Bioluminescent imaging (BLI) is based on the detection of light emitted by living
cells expressing a luciferase gene. Stable transfection of luciferase in cancer cells and their …
cells expressing a luciferase gene. Stable transfection of luciferase in cancer cells and their …
[HTML][HTML] Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model
J Poutou, M Bunuales, M Gonzalez-Aparicio… - Gene Therapy, 2015 - nature.com
Gene transfer of potent immunostimulatory cytokines such as interleukin-12 (IL-12) is a
potential treatment for advanced cancer. Different vectors and IL-12 modifications have been …
potential treatment for advanced cancer. Different vectors and IL-12 modifications have been …
The involvement of ADAM10 in acantholysis in mucocutaneous pemphigus vulgaris depends on the autoantibody profile of each patient
M Ivars, A España, P Alzuguren… - British Journal of …, 2020 - academic.oup.com
Background Acantholysis in pemphigus vulgaris (PV) may be triggered by desmoglein (Dsg)
and non‐Dsg autoantibodies. The autoantibody profile of each patient results in distinct …
and non‐Dsg autoantibodies. The autoantibody profile of each patient results in distinct …
Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector
M Guan, JR Rodriguez-Madoz, P Alzuguren, C Gomar… - Cancer research, 2006 - AACR
An improved viral vector for cancer gene therapy should be capable of infecting tumors with
high efficiency, inducing specific and high-level expression of transgene in the tumor and …
high efficiency, inducing specific and high-level expression of transgene in the tumor and …
Self-inactivating helper virus for the production of high-capacity adenoviral vectors
M Gonzalez-Aparicio, I Mauleon, P Alzuguren… - Gene Therapy, 2011 - nature.com
Standard methods for producing high-capacity adenoviral vectors (HC-Ads) are based on co-
infection with a helper adenovirus (HV). To avoid HV encapsidation, its packaging signal (Ψ) …
infection with a helper adenovirus (HV). To avoid HV encapsidation, its packaging signal (Ψ) …
Deletion of the E3-6.7 K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters
S Bortolanza, M Bunuales, P Alzuguren, O Lamas… - Cancer gene …, 2009 - nature.com
A partial deletion of the adenovirus E3 region, comprising the overlapping 6.7 K/gp19K
genes, has been described for the incorporation of therapeutic genes in 'armed'oncolytic …
genes, has been described for the incorporation of therapeutic genes in 'armed'oncolytic …
Liver damage using suicide genes: a model for oval cell activation
M Bustos, B Sangro, P Alzuguren, AG Gil, J Ruiz… - The American journal of …, 2000 - Elsevier
Liver regeneration from the facultative hepatic stem cells, the oval cells, takes place in
situations in which liver regeneration from pre-existing hepatocytes is prevented. Different …
situations in which liver regeneration from pre-existing hepatocytes is prevented. Different …
Human adenovirus replicates in immunocompetent models of pancreatic cancer in Syrian hamsters
S Bortolanza, P Alzuguren, M Buñuales, C Qian… - Human gene …, 2007 - liebertpub.com
The preclinical evaluation of toxicity and antitumor effect of conditionally replicative
(oncolytic) adenoviruses is hampered by the inability of human adenoviruses to replicate …
(oncolytic) adenoviruses is hampered by the inability of human adenoviruses to replicate …