Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Oxidative stress and inflammation are the most important pathogenic events in the
development and progression of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) is …

The development of next-generation sequencing technology and the discovery of specific
antibodies targeting chemically modified nucleotides have paved the way for a new era of …

m6A RNA modification is implicated in multiple cellular responses. However, its function in
the innate immune cells is poorly understood. Here, we identified major m6A “writers” as the …

Background and Purpose—Ischemic postconditioning has been found to decrease brain
infarct area and spinal cord ischemic injury. In this study, we tested the hypothesis that …

Background No adjuvant treatment has been established for patients who remain at high
risk for hepatocellular carcinoma recurrence after curative-intent resection or ablation. We …

Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in
tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of …

Background Dynamic N 6-methyladenosine (m 6 A) modification was previously identified
as a ubiquitous post-transcriptional regulation that affected mRNA homeostasis. However …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Systemic
chemotherapy plays an important role in the treatment of patients with advanced liver …

In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to
immunotherapy such as interferon-α (IFN-α) would be very useful in the clinic. We found that …