Genomic alterations driving tumorigenesis result from the interaction of environmental
exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is …

Background and aims Hepatocellular carcinomas (HCCs) are heterogeneous aggressive
tumors with low rates of response to treatment at advanced stages. We screened a large …

To date, genomic analyses of hepatocellular carcinoma (HCC) have been limited to early
stages obtained from liver resection. We aim to describe the genomic profiling of HCC from …

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression.
Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation …

Background Hepatocellular carcinoma is a frequent consequence of alcohol-related liver
disease, with variable incidence among heavy drinkers. We did a genome-wide association …

Background & Aims Telomerase activation is the earliest event in hepatocellular carcinoma
(HCC) development. Thus, we aimed to elucidate the role of telomere length maintenance …

Recently, a loss of function variant (rs72613567) in 17‐beta‐hydroxysteroid dehydrogenase
13 (HSD17B13) has been identified as protective of nonalcoholic (NAFLD) and alcoholic …

Objective Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic
in human population (35%–80%). Recurrent clonal AAV2 insertions are associated with the …

Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and
adolescents. Despite overall good prognosis, PLCs display heterogeneous response to …

Cancer genomes are altered by various mutational processes and, like palimpsests, bear
the signatures of these different processes. The Palimpsest R package provides a complete …