By expressing two genes (hTERT and Cdk4), we have developed a method to reproducibly
generate continuously replicating human bronchial epithelial cell (HBEC) lines that provide …

Telomere shortening is the mechanism underlying replicative aging in fibroblasts. A variety
of reports now claim that inactivation of the p16INK4a/pRB pathway is required in addition to …

We evaluated the contribution of three genetic alterations (p53 knockdown, K-RASV12, and
mutant EGFR) to lung tumorigenesis using human bronchial epithelial cells (HBEC) …

We used CDK4/hTERT–immortalized normal human bronchial epithelial cells (HBEC) from
several individuals to study lung cancer pathogenesis by introducing combinations of …

Telomeres are the end regions of linear chromosomes, and in normal somatic cells the
lengths of telomeres shorten with successive cell divisions. Telomerase, a ribonucleoprotein …

Abstract Caveolin-1 (CAV1), an essential structural constituent of caveolae that plays an
important role in cellular processes such as transport and signaling, has been implicated in …

Telomerase is a ribonucleoprotein enzyme capable of adding hexanucleotide repeats onto
the ends of linear chromosomal DNA. Whereas normal somatic cells with a limited …

A therapeutic approach being investigated for a variety of pathologies is tissue regeneration
using a patient's own cells. Such studies have been hampered due to the difficulty in …

BACKGROUND: Although it is known that stress elevates the levels of pro-inflammatory
cytokines and promotes hyper-excitable central conditions, a causal relationship between …

Many stimuli causing 'stress' or DNA damage in cells can produce phenotypes that overlap
with telomere-based replicative senescence. In epithelial systems, the p16/RB pathway may …