[HTML][HTML] AMPK re-activation suppresses hepatic steatosis but its downregulation does not promote fatty liver development

N Boudaba, A Marion, C Huet, R Pierre, B Viollet… - …, 2018 - thelancet.com
Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with
disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated …

[HTML][HTML] A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

M Dos Santos, S Backer, F Auradé, MMK Wong… - Nature …, 2022 - nature.com
The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …

Driving Role of Interleukin‐2–Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of …

C Frantz, A Cauvet, A Durand, V Gonzalez… - Arthritis & …, 2022 - Wiley Online Library
Objective Systemic sclerosis (SSc) is a debilitating autoimmune disease characterized by
severe lung outcomes resulting in reduced life expectancy. Fra‐2–transgenic mice offer the …

Managerial style and well‐being among psychiatric nurses: A prospective study

N Gillet, A Le Gouge, R Pierre, J Bongro… - Journal of psychiatric …, 2019 - Wiley Online Library
Accessible summary What is known on the subject? Numerous studies have shown that
organizational and managerial factors have significant effects on nurses' workplace well …

[HTML][HTML] Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice

MS Girault, S Dupuis, C Ialy-Radio, L Stouvenel… - International Journal of …, 2021 - mdpi.com
Thanks to the analysis of an Interspecific Recombinant Congenic Strain (IRCS), we
previously defined the Mafq1 quantitative trait locus as an interval on mouse Chromosome 1 …

Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling

J Javary, N Allain-Courtois, N Saucisse, P Costet… - Gut, 2018 - gut.bmj.com
Objective The AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and
preclinical studies indicate that it could be a relevant therapeutic target. However, its …

Gain-of-function prolactin receptor variants are not associated with breast cancer and multiple fibroadenoma risk

Z Chakhtoura, F Laki, M Bernadet… - The Journal of …, 2016 - academic.oup.com
Context: In a cohort of 95 women with multiple breast fibroadenomas (MFAs), we recently
identified patients harboring germline heterozygous variants of the prolactin receptor …

[HTML][HTML] Generation and Characterization of a Transgenic Mouse That Specifically Expresses the Cre Recombinase in Spermatids

C Gobé, C Ialy-Radio, R Pierre, J Cocquet - Genes, 2023 - mdpi.com
Spermiogenesis is the step during which post-meiotic cells, called spermatids, undergo
numerous morphological changes and differentiate into spermatozoa. Thousands of genes …

[HTML][HTML] Cyclic fertilin-derived peptide stimulates in vitro human embryo development

AL Denizot, A L'Hostis, A Sallem, S Favier, R Pierre… - F&S Science, 2022 - Elsevier
Objective To study the cyclic fertilin peptide effects on preimplantation human
embryogenesis. Cyclic fertilin peptide reproduces the structure of the binding site of the …

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

MD Santos, S Backer, F Auradé, M Wong, M Wurmser… - bioRxiv, 2021 - biorxiv.org
The contractile properties of adult myofibers are shaped by their Myosin heavy chain (MYH)
isoform content. We identify by snATAC-seq a 42kb super-enhancer (SE) at the locus …