Next-generation sequencing (NGS) application in clinical practice requires the
implementation of molecular tumor boards (MTBs). Starting from a systematic review of …

Simple Summary Tumor mutational burden (TMB) represents the number of mutations per
megabase (muts/Mb) harbored by tumor cells in a given neoplasm, and can be determined …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered
frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1 …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait
is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases …

Background & Aims Biliary tract cancers (BTCs) are clinically and pathologically
heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer …

Intraductal neoplasms are important precursors to invasive pancreatic cancer and provide
an opportunity to detect and treat pancreatic neoplasia before an invasive carcinoma …

Histopathological samples are a treasure-trove of DNA for clinical research. However, the
quality of DNA can vary depending on the source or extraction method applied. Thus a …