EGF receptor ligands

RC Harris, E Chung, RJ Coffey - The EGF Receptor Family, 2003 - Elsevier
Publisher Summary This chapter focuses on epidermal growth factor (EGF) receptor ligands.
The mammalian ligands that bind the EGF receptor (EGFR [HER1, Erb-B1]) include EGF …

[HTML][HTML] Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Pathology of mouse models of intestinal cancer: consensus report and recommendations

GP Boivin, K Washington, K Yang, JM Ward… - Gastroenterology, 2003 - Elsevier
The marked diversity in the phenotype of intestinal neoplasia in murine models offers
opportunities to model many characteristics of human CRC, including tumor progression …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

[HTML][HTML] Reassessment of exosome composition

DK Jeppesen, AM Fenix, JL Franklin, JN Higginbotham… - Cell, 2019 - cell.com
The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular
matter have led to debate about contents and functional properties of exosomes. Here, we …

Proteogenomic characterization of human colon and rectal cancer

B Zhang, J Wang, X Wang, J Zhu, Q Liu, Z Shi… - Nature, 2014 - nature.com
Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

CE Eberhart, RJ Coffey, A Radhika, FM Giardiello… - Gastroenterology, 1994 - Elsevier
Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

DW Threadgill, AA Dlugosz, LA Hansen… - Science, 1995 - science.org
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus
(Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 …

Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

AE Lang, S Gill, NK Patel, A Lozano, JG Nutt… - Annals of …, 2006 - Wiley Online Library
Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence
on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed …

Stereotactic radiosurgery for arteriovenous malformations of the brain

LD Lunsford, D Kondziolka, JC Flickinger… - Journal of …, 1991 - thejns.org
✓ Stereotactic radiosurgery successfully obliterates carefully selected arteriovenous
malformations (AVM's) of the brain. In an initial 3-year experience using the 201-source …