Pancreatic cancer: basic and clinical aspects
G Schneider, JT Siveke, F Eckel, RM Schmid - Gastroenterology, 2005 - gastrojournal.org
More than 30,000 people develop pancreatic adeno-carcinoma each year in the United
States, and almost all are expected to die from the disease. 1 The 5-year survival rate is 5 …
States, and almost all are expected to die from the disease. 1 The 5-year survival rate is 5 …
[HTML][HTML] Apoptotic pathways in pancreatic ductal adenocarcinoma
R Hamacher, RM Schmid, D Saur, G Schneider - Molecular cancer, 2008 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer
related death. Despite the advances in understanding of the molecular pathogenesis …
related death. Despite the advances in understanding of the molecular pathogenesis …
[HTML][HTML] Genetic alterations in pancreatic carcinoma
G Schneider, RM Schmid - Molecular cancer, 2003 - Springer
Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the
Western population with an average survival after diagnosis of 3 to 6 months and a five-year …
Western population with an average survival after diagnosis of 3 to 6 months and a five-year …
[HTML][HTML] Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek… - Cell, 2013 - cell.com
Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional
conversion between tumor-initiating stem cells and nonstem cells triggered by an …
conversion between tumor-initiating stem cells and nonstem cells triggered by an …
Identification, culture, and characterization of pancreatic stellate cells in rats and humans
MG Bachem, E Schneider, H Groß, H Weidenbach… - Gastroenterology, 1998 - Elsevier
Background & Aims: Until now, the basic matrix-producing cell type responsible for pancreas
fibrosis has not been identified. In this report, retinoid-containing pancreatic stellate cells …
fibrosis has not been identified. In this report, retinoid-containing pancreatic stellate cells …
[PDF][PDF] gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
J Bollrath, TJ Phesse, VA von Burstin, T Putoczki… - Cancer cell, 2009 - cell.com
Although gastrointestinal cancers are frequently associated with chronic inflammation, the
underlying molecular links have not been comprehensively deciphered. Using loss-and gain …
underlying molecular links have not been comprehensively deciphered. Using loss-and gain …
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.
C Wahl, S Liptay, G Adler… - The Journal of clinical …, 1998 - Am Soc Clin Investig
Transcription factors of the NF-kappaB/Rel family are critical for inducible expression of
multiple genes involved in inflammatory responses. Sulfasalazine and its salicylate moiety 5 …
multiple genes involved in inflammatory responses. Sulfasalazine and its salicylate moiety 5 …
[PDF][PDF] Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
M Lesina, MU Kurkowski, K Ludes, S Rose-John… - Cancer cell, 2011 - cell.com
Physiological levels of Kras G12D are sufficient to induce pancreatic intraepithelial
neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we …
neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we …
[PDF][PDF] Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Notch signaling regulates cell fate decisions in a wide variety of adult and embryonic
tissues. Here we show that Notch pathway components and Notch target genes are …
tissues. Here we show that Notch pathway components and Notch target genes are …
[HTML][HTML] NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ
FR Greten, MC Arkan, J Bollrath, LC Hsu, J Goode… - Cell, 2007 - cell.com
IKKβ-dependent NF-κB activation plays a key role in innate immunity and inflammation, and
inhibition of IKKβ has been considered as a likely anti-inflammatory therapy. Surprisingly …
inhibition of IKKβ has been considered as a likely anti-inflammatory therapy. Surprisingly …