The PREMM1, 2, 6 model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history
F Kastrinos, EW Steyerberg, R Mercado, J Balmaña… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS:: We developed and validated a model to estimate the risks of
mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal …
mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal …
Sharing genetic test results in Lynch syndrome: communication with close and distant relatives
EM Stoffel, B Ford, RC Mercado, D Punglia… - Clinical …, 2008 - Elsevier
Background & Aims: Clinical genetic testing can help direct cancer screening for members of
Lynch syndrome families; however, there is limited information about family communication …
Lynch syndrome families; however, there is limited information about family communication …
Germline TP53 mutations in patients with early-onset colorectal cancer in the colon cancer family registry
MB Yurgelun, S Masciari, VA Joshi, RC Mercado… - JAMA …, 2015 - jamanetwork.com
Importance Li-Fraumeni syndrome, usually characterized by germlineTP53mutations, is
associated with markedly elevated lifetime risks of multiple cancers, and has been linked to …
associated with markedly elevated lifetime risks of multiple cancers, and has been linked to …
Phenotype Comparison of MLH1 and MSH2 Mutation Carriers in a Cohort of 1,914 Individuals Undergoing Clinical Genetic Testing in the United States
F Kastrinos, EM Stoffel, J Balmana… - … Biomarkers & Prevention, 2008 - AACR
Abstract Background and Aims: Lynch syndrome is caused by germ-line mismatch repair
gene mutations. We examined the phenotypic differences between MLH1 and MSH2 gene …
gene mutations. We examined the phenotypic differences between MLH1 and MSH2 gene …
Prevalence and predictors of appropriate colorectal cancer surveillance in Lynch syndrome
EM Stoffel, RC Mercado, W Kohlmann… - Official journal of the …, 2010 - journals.lww.com
OBJECTIVES: Lynch syndrome (LS) is a hereditary cancer syndrome that conveys a high
risk of colorectal cancer (CRC). Guidelines recommend colonoscopy every 1 to 2 years …
risk of colorectal cancer (CRC). Guidelines recommend colonoscopy every 1 to 2 years …
Comparison of prediction models for Lynch syndrome among individuals with colorectal cancer
F Kastrinos, RP Ojha, C Leenen… - Journal of the …, 2016 - academic.oup.com
Background: Recent guidelines recommend the Lynch Syndrome prediction models
MMRPredict, MMRPro, and PREMM1, 2, 6 for the identification of MMR gene mutation …
MMRPredict, MMRPro, and PREMM1, 2, 6 for the identification of MMR gene mutation …
Intimate partner violence among women veterans: Previous interpersonal violence as a risk factor
KM Iverson, R Mercado, SL Carpenter… - Journal of Traumatic …, 2013 - Wiley Online Library
Experiences of abuse during childhood or military service may increase women veterans'
risk for intimate partner violence (IPV) victimization. This study examined the relative impact …
risk for intimate partner violence (IPV) victimization. This study examined the relative impact …
Comparison of the clinical prediction model PREMM1, 2, 6 and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer
F Kastrinos, EW Steyerberg, J Balmaña, R Mercado… - Gut, 2013 - gut.bmj.com
Background Lynch syndrome is caused by germline mismatch repair (MMR) gene
mutations. The PREMM1, 2, 6 model predicts the likelihood of a MMR gene mutation based …
mutations. The PREMM1, 2, 6 model predicts the likelihood of a MMR gene mutation based …
Impact of childhood abuse on physical and mental health status and health care utilization among female veterans
RC Mercado, S Wiltsey-Stirman, KM Iverson - Military Medicine, 2015 - academic.oup.com
Objective: To determine whether childhood abuse predicts health symptoms and health care
use among female veterans. Methods: Participants were 369 female patients at Veterans …
use among female veterans. Methods: Participants were 369 female patients at Veterans …
[HTML][HTML] Performance of PREMM1, 2, 6, MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer cases
RC Mercado, H Hampel, F Kastrinos… - Genetics in …, 2012 - nature.com
Purpose: Lynch syndrome accounts for 2–5% of endometrial cancer cases. Lynch syndrome
prediction models have not been evaluated among endometrial cancer cases. Methods …
prediction models have not been evaluated among endometrial cancer cases. Methods …