User profiles for "author:S Elena"
Santiago F. ElenaProfessor, CSIC Verified email at uv.es Cited by 20189 |
Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
Microorganisms have been mutating and evolving on Earth for billions of years. Now, a field
of research has developed around the idea of using microorganisms to study evolution in …
of research has developed around the idea of using microorganisms to study evolution in …
Perspective: evolution and detection of genetic robustness
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of
phenotypes appears at various levels of biological organization, including gene expression …
phenotypes appears at various levels of biological organization, including gene expression …
Basic concepts in RNA virus evolution
A hallmark of RNA genomes is the error‐prone nature of their Replication and retro‐
transcription. The major biochemical basis of the limited replication fidelity is the absence of …
transcription. The major biochemical basis of the limited replication fidelity is the absence of …
The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
Little is known about the mutational fitness effects associated with single-nucleotide
substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 …
substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 …
T (11; 18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication
…, G Caletti, T Wündisch, T Molina, BG Taal, S Elena… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS: Eradication of Helicobacter pylori leads to cure of gastric mucosa-
associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However …
associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However …
Test of synergistic interactions among deleterious mutations in bacteria
Identifying the forces responsible for the origin and maintenance of sexuality remains one of
the greatest unsolved problems in biology,,,,,. The mutational deterministic hypothesis …
the greatest unsolved problems in biology,,,,,. The mutational deterministic hypothesis …
Punctuated evolution caused by selection of rare beneficial mutations
For more than two decades there has been intense debate over the hypothesis that most
morphological evolution occurs during relatively brief episodes of rapid change that …
morphological evolution occurs during relatively brief episodes of rapid change that …
Adaptive value of high mutation rates of RNA viruses: separating causes from consequences
SF Elena, R Sanjuán - Journal of virology, 2005 - Am Soc Microbiol
As a consequence of the lack of proofreading activity of RNA virus polymerases, new viral
genetic variants are constantly created. RNA viruses readily adapt to changing …
genetic variants are constantly created. RNA viruses readily adapt to changing …
Intellectual capital in universities: Improving transparency and internal management
M Paloma Sánchez, S Elena - Journal of intellectual capital, 2006 - emerald.com
Purpose–The growing interest regarding intangibles and intellectual capital (IC) has
extended from firms to public institutions such as universities and research centres during …
extended from firms to public institutions such as universities and research centres during …
Intellectual capital dynamics in universities: a reporting model
M Paloma Sánchez, S Elena… - Journal of intellectual …, 2009 - emerald.com
Purpose–The purpose of this paper is to analyse the increasing attention to universities and
research organizations at political level and the growing implementation in these institutions …
research organizations at political level and the growing implementation in these institutions …