[HTML][HTML] The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney

H Kulaksiz, F Theilig, S Bachmann… - Journal of …, 2005 - joe.bioscientifica.com
It is generally accepted that iron homeostasis is mainly controlled in the gastrointestinal tract
by absorption of dietary iron. However, recent studies have shown that the kidneys are also …

Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia

H Kulaksiz, SG Gehrke, A Janetzko, D Rost, T Bruckner… - Gut, 2004 - gut.bmj.com
Background and aims: The hepatic peptide hormone hepcidin, which has recently been
isolated from human plasma and urine, is thought to be a central regulator of iron …

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

SG Gehrke, H Kulaksiz, T Herrmann, HD Riedel… - Blood, 2003 - ashpublications.org
Experimental data suggest the antimicrobial peptide hepcidin as a central regulator in iron
homeostasis. In this study, we characterized the expression of human hepcidin in …

The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation

U Merle, E Fein, SG Gehrke, W Stremmel… - …, 2007 - academic.oup.com
The peptide hormone hepcidin plays a central role in iron homeostasis. It is predominantly
expressed in the liver and regulated by iron, hypoxia, and inflammation. Although it has …

Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-κB and activator protein 1 in a redox-sensitive …

M Browatzki, D Larsen, CAH Pfeiffer… - Journal of vascular …, 2005 - karger.com
The renin-angiotensin system contributes to atherogenesis. Matrix metalloproteinases
(MMP) are thought to participate in plaque destabilization through degradation of …

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin

T Herrmann, M Muckenthaler… - Journal of molecular …, 2004 - Springer
Patients suffering from hereditary hemochromatosis (HH) show progressive iron overload as
a consequence of increased duodenal iron absorption. It has been hypothesized that …

Iron, the HFE gene, and hepatitis C

C Eisenbach, SG Gehrke, W Stremmel - Clinics in Liver Disease, 2004 - liver.theclinics.com
The hepatitis C virus (HCV) is an enveloped, positive-stranded RNA virus belonging to the
group of Flaviviridae and was first cloned in 1989 [1]. HCV has been identified as the major …

HJV gene mutations in European patients with juvenile hemochromatosis

SG Gehrke, A Pietrangelo, M Kaščįk, A Braner… - Clinical …, 2005 - Wiley Online Library
A large variety of mutations within the genes encoding hepcidin (HAMP) and hemojuvelin
(HJV) have been identified in patients with the severe iron overload disorder juvenile …

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells

HD Riedel, MU Muckenthaler… - Blood, The Journal …, 1999 - ashpublications.org
Hereditary hemochromatosis (HH) is a common autosomal-recessive disorder of iron
metabolism. More than 80% of HH patients are homozygous for a point mutation in a major …

Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype

SG Gehrke, W Stremmel, I Mathes, HD Riedel… - Journal of molecular …, 2003 - Springer
Mild iron overload in chronic hepatitis C is associated with liver fibrosis, hepatitis C virus
(HCV) genotype 1b infection, and an impaired response to interferon therapy. In this study …