British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
Intestinal stem cells
The intestinal tract has a rapid epithelial cell turnover, which continues throughout life. The
process is regulated and maintained by a population of stem cells, which give rise to all the …
process is regulated and maintained by a population of stem cells, which give rise to all the …
The safety of autologous fat transfer in breast cancer: lessons from stem cell biology
RA Pearl, SJ Leedham, MD Pacifico - Journal of plastic, reconstructive & …, 2012 - Elsevier
Autologous fat grafting is versatile tool in plastic surgery and is increasing used for
reconstruction following breast conserving surgery for breast cancer. Part of the …
reconstruction following breast conserving surgery for breast cancer. Part of the …
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves, SL Preston, PJ Tadrous… - Proceedings of the …, 2006 - National Acad Sciences
The understanding of the fixation of mutations within human tissues and their subsequent
clonal expansion is a considerable problem, of which little is known. We have previously …
clonal expansion is a considerable problem, of which little is known. We have previously …
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-
morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in …
morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in …
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
SAC McDonald, LC Greaves, L Gutierrez–Gonzalez… - Gastroenterology, 2008 - Elsevier
Background & Aims: How mutations are established and spread through the human
stomach is unclear because the clonal structure of gastric mucosal units is unknown. Here …
stomach is unclear because the clonal structure of gastric mucosal units is unknown. Here …
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus
SJ Leedham, SL Preston, SAC McDonald, G Elia… - Gut, 2008 - gut.bmj.com
Objectives: Current models of clonal expansion in human Barrett's oesophagus are based
upon heterogenous, flow-purified biopsy analysis taken at multiple segment levels …
upon heterogenous, flow-purified biopsy analysis taken at multiple segment levels …
[PDF][PDF] Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
EG Vazquez, N Nasreddin, GN Valbuena… - Cell Stem Cell, 2022 - cell.com
Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs),
but following injury, dedifferentiation results in the emergence of LGR5− ve regenerative …
but following injury, dedifferentiation results in the emergence of LGR5− ve regenerative …
The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis
Background & Aims Cancer-associated fibroblasts (CAFs) play an important role in
colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However …
colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However …