In vivo Biology and Toxicology of Fullerenes and Their Derivatives

GD Nielsen, M Roursgaard, KA Jensen… - Basic & Clinical …, 2008 - Wiley Online Library
Fullerenes represent a group of nanoparticles discovered in 1985. They are spherical
molecules consisting entirely of carbon atoms (Cx) to which side chains can be added …

[HTML][HTML] Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

Particle‐induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

AT Saber, NR Jacobsen, P Jackson… - Wiley …, 2014 - Wiley Online Library
Inhalation of ambient and workplace particulate air pollution is associated with increased
risk of cardiovascular disease. One proposed mechanism for this association is that …

Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas

C ØRSKOV, JJ Holst, S Knuhtsen… - …, 1986 - academic.oup.com
We developed specific antibodies and RIAs for glucagon-like peptides 1 and 2 (GLP-1 and
GLP-2), two predicted products of the glucagon gene, and studied the occurrence, nature …

Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

PB Jeppesen, B Hartmann, J Thulesen, J Graff… - Gastroenterology, 2001 - Elsevier
Background & Aims: Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and
transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the …

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin

KL Egerod, MS Engelstoft, KV Grunddal… - …, 2012 - academic.oup.com
Enteroendocrine cells such as duodenal cholecystokinin (CCK cells) are generally thought
to be confined to certain segments of the gastrointestinal (GI) tract and to store and release …

Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I

C Ørskov, SS Poulsen, M Mørten, JJ Holst - Diabetes, 1996 - Am Diabetes Assoc
The intestinal incretin hormone glucagon-like peptide I (GLP-I) inhibits gastric motility and
secretion in normal, but not in vagotomized subjects, pointing to a centrally mediated effect …

Effect of trefoil factors on the viscoelastic properties of mucus gels

L Thim, F Madsen, SS Poulsen - European journal of clinical …, 2002 - Wiley Online Library
Abstract Background Trefoil peptides (TFFs) are expressed and secreted in a tissue‐specific
manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins …

Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

PB Jeppesen, B Hartmann, J Thulesen, BS Hansen… - Gut, 2000 - gut.bmj.com
BACKGROUND The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from
L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is …

GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors

C Ørskov, B Hartmann, SS Poulsen, J Thulesen… - Regulatory peptides, 2005 - Elsevier
BACKGROUND: Glucagon-like peptide-2 is thought to act as a growth factor for the gut, but
the localization of the GLP-2 receptor and mechanism of action on epithelial growth is …