User profiles for "author:Satya Prakash"
Dr. Satya PrakashProfessor of Biomedical Engineering, Faculty of Medicine and Health Sciences, McGill … Verified email at mcgill.ca Cited by 20317 |
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function
S Prakash, RE Johnson, L Prakash - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …
Nucleotide excision repair in yeast
S Prakash, L Prakash - Mutation Research/Fundamental and Molecular …, 2000 - Elsevier
In nucleotide excision repair (NER) in eukaryotes, DNA is incised on both sides of the lesion,
resulting in the removal of a fragment∼ 25–30 nucleotides long. This is followed by repair …
resulting in the removal of a fragment∼ 25–30 nucleotides long. This is followed by repair …
[PDF][PDF] The Y-family of DNA polymerases
H Ohmori, EC Friedberg, RPP Fuchs, MF Goodman… - Molecular cell, 2001 - cell.com
selves, exhibit little homology to any of the five previously identified polymerase families.
This new family of polymerases has been described in the literature as the Based on …
This new family of polymerases has been described in the literature as the Based on …
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Polη
RE Johnson, S Prakash, L Prakash - Science, 1999 - science.org
The RAD30 gene of the yeast Saccharomyces cerevisiae is required for the error-free
postreplicational repair of DNA that has been damaged by ultraviolet irradiation. Here …
postreplicational repair of DNA that has been damaged by ultraviolet irradiation. Here …
hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum
RE Johnson, CM Kondratick, S Prakash, L Prakash - Science, 1999 - science.org
Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by a high
incidence of skin cancers. Yeast RAD30 encodes a DNA polymerase involved in the error …
incidence of skin cancers. Yeast RAD30 encodes a DNA polymerase involved in the error …
Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
RE Johnson, MT Washington, L Haracska, S Prakash… - Nature, 2000 - nature.com
DNA lesions can often block DNA replication, so cells possess specialized low-fidelity, and
often error-prone, DNA polymerases that can bypass such lesions and promote replication …
often error-prone, DNA polymerases that can bypass such lesions and promote replication …
[HTML][HTML] Fidelity of human DNA polymerase η
RE Johnson, MT Washington, S Prakash… - Journal of Biological …, 2000 - ASBMB
Xeroderma pigmentosum (XP) patients are highly sensitive to sunlight, and they suffer from
a high incidence of skin cancers. The variant form of XP results from mutations in …
a high incidence of skin cancers. The variant form of XP results from mutations in …
Efficient and accurate replication in the presence of 7, 8-dihydro-8-oxoguanine by DNA polymerase η
L Haracska, SL Yu, RE Johnson, L Prakash… - Nature …, 2000 - nature.com
Oxidative damage to DNA has been proposed to have a role in cancer and ageing 1.
Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in …
Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in …
[PDF][PDF] Structure of the catalytic core of S. cerevisiae DNA polymerase η: implications for translesion DNA synthesis
J Trincao, RE Johnson, CR Escalante, S Prakash… - Molecular cell, 2001 - cell.com
DNA polymerase η is unique among eukaryotic polymerases in its proficient ability to
replicate through a variety of distorting DNA lesions. We report here the crystal structure of …
replicate through a variety of distorting DNA lesions. We report here the crystal structure of …