Laboratory markers have been investigated in inflammatory bowel disease (IBD) for
diagnostic and differential diagnostic purposes, for assessment of disease activity and risk of …

Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

Fistulating Crohn's disease (CD) comprises fistulae arising in the perianal area, together
with those communicating between the intestine and other organs or the abdominal wall …

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

The discovery of a series of genetic and serological markers associated with disease
susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an …

In recent years, investigators have readdressed the complex issues involved in the
classification of inflammatory bowel diseases. In 2003, a Working Party of investigators with …

Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Background Treatment with infliximab, a chimeric monoclonal IgG1 antibody against tumor
necrosis factor, can result in the formation of antibodies against infliximab. We evaluated the …

Objective Bacteria play an important role in the onset and perpetuation of intestinal
inflammation in inflammatory bowel disease (IBD). Unlike in Crohn's disease (CD), in which …