Lectin-carbohydrate interactions: different folds, common recognition principles

S Elgavish, B Shaanan - Trends in biochemical sciences, 1997 - cell.com
Lectins can be found in many organisms and are involved in a multitude of cellular
processes that depend on specific recognition of complex carbohydrates. The …

Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the …

EB Rubin, Y Shemesh, M Cohen, S Elgavish… - Genome …, 2006 - genome.cshlp.org
The circadian clock of the honey bee is implicated in ecologically relevant complex
behaviors. These include time sensing, time-compensated sun-compass navigation, and …

Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation

P Malakar, A Shilo, A Mogilevsky, I Stein, E Pikarsky… - Cancer research, 2017 - AACR
Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise
contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is …

[HTML][HTML] Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity

Y Schlesinger, O Yosefov-Levi, D Kolodkin-Gal… - Nature …, 2020 - nature.com
Acinar metaplasia is an initial step in a series of events that can lead to pancreatic cancer.
Here we perform single-cell RNA-sequencing of mouse pancreas during the progression …

Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in …

O Alfi, A Yakirevitch, O Wald, O Wandel, U Izhar… - Journal of …, 2021 - Am Soc Microbiol
The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate …

Zika virus infects early-and midgestation human maternal decidual tissues, inducing distinct innate tissue responses in the maternal-fetal interface

Y Weisblum, E Oiknine-Djian, OM Vorontsov… - Journal of …, 2017 - Am Soc Microbiol
Zika virus (ZIKV) has emerged as a cause of congenital brain anomalies and a range of
placenta-related abnormalities, highlighting the need to unveil the modes of maternal-fetal …

[HTML][HTML] Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase

G Abboud-Jarrous, Z Rangini-Guetta, H Aingorn… - Journal of Biological …, 2005 - ASBMB
Heparanase is an endo-β-d-glucuronidase that degrades heparan sulfate in the
extracellular matrix and cell surfaces. Human proheparanase is produced as a latent 65-kDa …

Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

N Rosenberg, M Van Haele, T Lanton, N Brashi… - Journal of …, 2022 - Elsevier
Background & Aims Primary liver cancers include hepatocellular carcinoma (HCC),
intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It …

The genetic program of pancreatic β-cell replication in vivo

A Klochendler, I Caspi, N Corem, M Moran… - Diabetes, 2016 - Am Diabetes Assoc
The molecular program underlying infrequent replication of pancreatic β-cells remains
largely inaccessible. Using transgenic mice expressing green fluorescent protein in cycling …

[HTML][HTML] Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor …

G Ayalon, E Segev, S Elgavish, Y Stern-Bach - Journal of Biological …, 2005 - ASBMB
The N-terminal domain (NTD) of α-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)
and kainate glutamate receptors plays an important role in controlling subtype specific …