Intrahepatic cholangiocarcinomas (ICCs) are primary liver tumors with a poor prognosis. The
development of effective therapies has been hampered by a limited understanding of the …

BACKGROUND & AIMS: Cancer cells often lose contact inhibition to undergo anchorage-
independent proliferation and become resistant to apoptosis by inactivating the Hippo …

Background & Aims Aberrant activation of β-catenin and Yes-associated protein 1 (Yap1)
signaling pathways have been associated with the development of multiple tumor types. Yap …

Background & Aims Changes to the microenvironment of pancreatic ductal
adenocarcinomas (PDACs) have been associated with poor outcomes of patients. We …

Amplification and/or activation of the c‐Myc proto‐oncogene is one of the leading genetic
events along hepatocarcinogenesis. The oncogenic potential of c‐Myc has been proven …

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have
been independently described in many tumour types, including hepatocellular carcinoma …

Background & Aims Cumulating evidence underlines the crucial role of aberrant lipogenesis
in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of …

Based on their lobule location, hepatocytes display differential gene expression, including
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …

Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in
the development of human hepatocellular carcinoma (HCC). To elucidate the functional …

Background & Aims Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is
upregulated in many tumor types and is a promising target for cancer therapy. Herein, we …