The rat is immature at birth and undergoes major developmental changes at the end of the
suckling period. This review deals with the maturation of ingestive behavior, gastrointestinal …

Many advances have been reported in the long-term culture of intestinal mucosal cells in
recent years. A significant number of publications have described new culture media, cell …

In this review, the rat is used as a model system for a discussion of the postnatal
development of intestinal enzymes. Emphasis is placed on the regulation and mechanisms …

The canonical Wnt/β-catenin signalling pathway governs diverse developmental,
homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface …

A sensitive protein-binding assay has been used to measure plasma concentrations of total
corticosterone during postnatal development in the rat. These concentrations were …

Several cell populations have been reported to possess intestinal stem cell (ISC) activity
during homeostasis and injury-induced regeneration. Here, we explored inter-relationships …

Background & Aims: Math1 (Atoh1) is a basic helix-loop-helix transcription factor important
for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell …

The gastrointestinal (GI) tract forms from the endoderm (which gives rise to the epithelium)
and the mesoderm (which develops into the smooth muscle layer, the mesenchyme, and …

The intestinal epithelium is in a constant state of renewal. The rapid turnover of cells is fed
by a hierarchy of transit amplifying and stem/progenitor cells destined to give rise to the four …

Sustained increases in mucosal surface area occur in remaining bowel following massive
intestinal loss. The mechanisms responsible for expanding and perpetuating this response …