Pathogenesis of nonalcoholic steatohepatitis

W Liu, RD Baker, T Bhatia, L Zhu, SS Baker - Cellular and Molecular Life …, 2016 - Springer
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease and
a risk factor for cirrhosis and hepatocellular carcinoma. The pathological features of NASH …

Gastrointestinal outcomes and confounders in cystic fibrosis

D Borowitz, PR Durie, LL Clarke… - Journal of pediatric …, 2005 - journals.lww.com
Until the mid 20th century, children with cystic fibrosis (CF) died at a young age from a
combination of malnutrition and suppurative lung disease. In the past three to four decades …

[HTML][HTML] Gut microbiome and nonalcoholic fatty liver diseases

L Zhu, RD Baker, SS Baker - Pediatric research, 2015 - nature.com
We review recent findings and hypotheses on the roles of gut microbiome in the
pathogenesis of nonalcoholic fatty liver diseases (NAFLD). Microbial metabolites and cell …

[PDF][PDF] Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH

L Zhu, SS Baker, C Gill, W Liu, R Alkhouri… - …, 2013 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) is a serious liver disease associated with obesity.
Characterized by metabolic syndrome, hepatic steatosis, and liver inflammation, NASH is …

Constipation in infants and children: evaluation and treatment

SS Baker, GS Liptak, RB Colletti… - Journal of pediatric …, 1999 - journals.lww.com
BACKGROUND A normal pattern of stool evacuation is thought to be a sign of health in
children of all ages. Especially during the first months of life, parents pay close attention to …

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

S Kugathasan, LA Denson, TD Walters, MO Kim… - The Lancet, 2017 - thelancet.com
Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …

[HTML][HTML] Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Y Haberman, TL Tickle, PJ Dexheimer… - The Journal of …, 2014 - Am Soc Clin Investig
Interactions between the host and gut microbial community likely contribute to Crohn
disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of …

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

NA Jiao, SS Baker, A Chapa-Rodriguez, W Liu… - Gut, 2018 - gut.bmj.com
Objective Bile acids are regulators of lipid and glucose metabolism, and modulate
inflammation in the liver and other tissues. Primary bile acids such as cholic acid and …

Structural changes in the gut microbiome of constipated patients

L Zhu, W Liu, R Alkhouri, RD Baker… - Physiological …, 2014 - journals.physiology.org
Previous studies using culture-based methods suggested an association between
constipation and altered abundance of certain taxa of the colonic microbiome. We aim to …

[HTML][HTML] Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Y Haberman, R Karns, PJ Dexheimer… - Nature …, 2019 - nature.com
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …