Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

S Deegan, S Saveljeva, AM Gorman… - Cellular and Molecular Life …, 2013 - Springer
Macroautophagy (autophagy) is a cellular catabolic process which can be described as a
self-cannibalism. It serves as an essential protective response during conditions of …

New directions in ER stress-induced cell death

SE Logue, P Cleary, S Saveljeva, A Samali - Apoptosis, 2013 - Springer
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of many
diseases including heart disease, cancer and neurodegenerative diseases such as …

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

N Powell, E Pantazi, P Pavlidis, A Tsakmaki, K Li… - Gut, 2020 - gut.bmj.com
Objective The functional role of interleukin-22 (IL22) in chronic inflammation is controversial,
and mechanistic insights into how it regulates target tissue are lacking. In this study, we …

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease–like ileitis

M Tschurtschenthaler, TE Adolph, JW Ashcroft… - Journal of Experimental …, 2017 - rupress.org
ATG16L1T300A, a major risk polymorphism in Crohn's disease (CD), causes impaired
autophagy, but it has remained unclear how this predisposes to CD. In this study, we report …

C13orf31 (FAMIN) is a central regulator of immunometabolic function

MZ Cader, K Boroviak, Q Zhang, G Assadi… - Nature …, 2016 - nature.com
Single-nucleotide variations in C13orf31 (LACC1) that encode p. C284R and p. I254V in a
protein of unknown function (called'FAMIN'here) are associated with increased risk for …

[HTML][HTML] ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

K Aden, F Tran, GO Ito, R Sheibani-Tezerji… - Journal of Experimental …, 2018 - rupress.org
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been
associated with defective autophagy and deregulation of endoplasmic reticulum (ER) …

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment

E Pagano, JE Elias, G Schneditz, S Saveljeva… - Gut, 2022 - gut.bmj.com
Objective Primary sclerosing cholangitis (PSC) is in 70% of cases associated with
inflammatory bowel disease. The hypermorphic T108M variant of the orphan G protein …

[HTML][HTML] Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

S Saveljeva, P Cleary, K Mnich, A Ayo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Upregulation of SESTRIN 2 (SESN2) has been reported in response to diverse
cellular stresses. In this study we demonstrate SESTRIN 2 induction following endoplasmic …

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

G Schneditz, JE Elias, E Pagano, M Zaeem Cader… - Science …, 2019 - science.org
The sodium potassium pump (Na/K-ATPase) ensures the electrochemical gradient of a cell
through an energy-dependent process that consumes about one-third of regenerated ATP …

[PDF][PDF] A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

S Saveljeva, GW Sewell, K Ramshorn, MZ Cader… - Cell metabolism, 2022 - cell.com
Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a
cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of …