Clinical diagnosis and staging of cholangiocarcinoma
B Blechacz, M Komuta, T Roskams… - Nature reviews …, 2011 - nature.com
Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing
to its anatomic location, growth patterns and lack of definite diagnostic criteria. Currently …
to its anatomic location, growth patterns and lack of definite diagnostic criteria. Currently …
Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
T Roskams - Oncogene, 2006 - nature.com
In the liver, several cell types have the longevity that is needed to be the cell of origin of a
cancer: hepatocytes, cholangiocytes and progenitor cells. The latter are located in the most …
cancer: hepatocytes, cholangiocytes and progenitor cells. The latter are located in the most …
Progenitor cells in diseased human liver
TA Roskams, L Libbrecht… - Seminars in liver …, 2003 - thieme-connect.com
Hepatic progenitor cells are immature epithelial cells that reside in the smallest ramifications
of the biliary tree in human liver. These cells are capable of differentiating toward the biliary …
of the biliary tree in human liver. These cells are capable of differentiating toward the biliary …
Serum markers detect the presence of liver fibrosis: a cohort study
WMC Rosenberg, M Voelker, R Thiel, M Becka, A Burt… - Gastroenterology, 2004 - Elsevier
Background & Aims: Histologic examination of a liver biopsy specimen is regarded as the
reference standard for detecting liver fibrosis. Biopsy can be painful and hazardous, and …
reference standard for detecting liver fibrosis. Biopsy can be painful and hazardous, and …
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
JS Lee, J Heo, L Libbrecht, IS Chu, P Kaposi-Novak… - Nature medicine, 2006 - nature.com
The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
[PDF][PDF] Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
TA Roskams, ND Theise, C Balabaud, G Bhagat… - …, 2004 - Wiley Online Library
The work of liver stem cell biologists, largely carried out in rodent models, has now started to
manifest in human investigations and applications. We can now recognize complex …
manifest in human investigations and applications. We can now recognize complex …
[PDF][PDF] Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
JS Lee, IS Chu, J Heo, DF Calvisi, Z Sun… - …, 2004 - Wiley Online Library
We analyzed global gene expression patterns of 91 human hepatocellular carcinomas
(HCCs) to define the molecular characteristics of the tumors and to test the prognostic value …
(HCCs) to define the molecular characteristics of the tumors and to test the prognostic value …
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
During chronic injury a population of bipotent hepatic progenitor cells (HPCs) become
activated to regenerate both cholangiocytes and hepatocytes. Here we show in human …
activated to regenerate both cholangiocytes and hepatocytes. Here we show in human …
[PDF][PDF] Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
The IκB kinase (IKK) subunit NEMO/IKKγ is essential for activation of the transcription factor
NF-κB, which regulates cellular responses to inflammation. The function of NEMO in the …
NF-κB, which regulates cellular responses to inflammation. The function of NEMO in the …
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors
JB Andersen, B Spee, BR Blechacz, I Avital, M Komuta… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Cholangiocarcinoma is a heterogeneous disease with a poor
outcome that accounts for 5%− 10% of primary liver cancers. We characterized its genomic …
outcome that accounts for 5%− 10% of primary liver cancers. We characterized its genomic …