User profiles for "author:Terence P Speed"

Terence P Speed

Walter & Eliza Hall Institute of Medical Research
Verified email at wehi.edu.au
Cited by 111210

Comparison of methods for image analysis on cDNA microarray data

YH Yang, MJ Buckley, S Dudoit… - Journal of computational …, 2002 - Taylor & Francis
Microarrays are part of a new class of biotechnologies which allow the monitoring of
expression levels for thousands of genes simultaneously. Image analysis is an important …

Regulation of apicomplexan actin-based motility

J Baum, AT Papenfuss, B Baum, TP Speed… - Nature Reviews …, 2006 - nature.com
Apicomplexan parasites are an ancient group of protozoan parasites that includes several
significant pathogens of humans and animals. To target and invade host cells they use a …

Analysis of cDNA microarray images

YH Yang, MJ Buckley, TP Speed - Briefings in bioinformatics, 2001 - academic.oup.com
Microarrays are part of a new class of biotechnologies that allow the monitoring of
expression levels for thousands of genes simultaneously. Image analysis is an important …

[PDF][PDF] Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

RGW Verhaak, KA Hoadley, E Purdom, V Wang, Y Qi… - Cancer cell, 2010 - cell.com
Summary The Cancer Genome Atlas Network recently cataloged recurrent genomic
abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression …

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

YH Yang, S Dudoit, P Luu, DM Lin, V Peng… - Nucleic acids …, 2002 - academic.oup.com
There are many sources of systematic variation in cDNA microarray experiments which
affect the measured gene expression levels (eg differences in labeling efficiency between …

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

RA Irizarry, B Hobbs, F Collin, YD Beazer‐Barclay… - …, 2003 - academic.oup.com
In this paper we report exploratory analyses of high‐density oligonucleotide array data from
the Affymetrix GeneChip® system with the objective of improving upon currently used …

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

BM Bolstad, RA Irizarry, M Åstrand, TP Speed - Bioinformatics, 2003 - academic.oup.com
Motivation: When running experiments that involve multiple high density oligonucleotide
arrays, it is important to remove sources of variation between arrays of non-biological origin …

Summaries of Affymetrix GeneChip probe level data

RA Irizarry, BM Bolstad, F Collin, LM Cope… - Nucleic acids …, 2003 - academic.oup.com
High density oligonucleotide array technology is widely used in many areas of biomedical
research for quantitative and highly parallel measurements of gene expression. Affymetrix …

Comparison of discrimination methods for the classification of tumors using gene expression data

S Dudoit, J Fridlyand, TP Speed - Journal of the American …, 2002 - Taylor & Francis
A reliable and precise classification of tumors is essential for successful diagnosis and
treatment of cancer. cDNA microarrays and high-density oligonucleotide chips are novel …

Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments

S Dudoit, YH Yang, MJ Callow, TP Speed - Statistica sinica, 2002 - JSTOR
DNA microarrays are a new and promising biotechnology which allows the monitoring of
expression levels in cells for thousands of genes simultaneously. The present paper …