User profiles for "author:Thaddeus S Stappenbeck"

Thaddeus S. Stappenbeck

Cleveland Clinic
Verified email at ccf.org
Cited by 33197

[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

The role of stromal stem cells in tissue regeneration and wound repair

TS Stappenbeck, H Miyoshi - Science, 2009 - science.org
The process of wound repair in epithelium-lined organs of mammals is complex and is
influenced by numerous secreted factors including cytokines, growth factors, and …

Genetics and pathogenesis of inflammatory bowel disease

TC Liu, TS Stappenbeck - Annual Review of Pathology …, 2016 - annualreviews.org
We are currently in an exciting time when our understanding of genetic underpinnings of
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel …

[PDF][PDF] A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility

MS Desai, AM Seekatz, NM Koropatkin, N Kamada… - Cell, 2016 - cell.com
Despite the accepted health benefits of consuming dietary fiber, little is known about the
mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk …

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

K Cadwell, JY Liu, SL Brown, H Miyoshi, J Loh… - Nature, 2008 - nature.com
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small
intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene …

[PDF][PDF] The colonic crypt protects stem cells from microbiota-derived metabolites

GE Kaiko, SH Ryu, OI Koues, PL Collins… - Cell, 2016 - cell.com
In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor
cells at their base. The mammalian intestine also harbors a diverse array of microbial …

Peripheral education of the immune system by colonic commensal microbiota

SK Lathrop, SM Bloom, SM Rao, K Nutsch, CW Lio… - Nature, 2011 - nature.com
The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity,
is facilitated by the education of T cells in a specialized organ, the thymus, in which self …

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

TS Stappenbeck, LV Hooper… - Proceedings of the …, 2002 - National Acad Sciences
The adult mouse intestine contains an intricate vascular network. The factors that control
development of this network are poorly understood. Quantitative three-dimensional imaging …

[HTML][HTML] Disease-specific alterations in the enteric virome in inflammatory bowel disease

JM Norman, SA Handley, MT Baldridge, L Droit, CY Liu… - Cell, 2015 - cell.com
Decreases in the diversity of enteric bacterial populations are observed in patients with
Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these …

[HTML][HTML] Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

K Cadwell, KK Patel, NS Maloney, TC Liu, ACY Ng… - Cell, 2010 - cell.com
It is unclear why disease occurs in only a small proportion of persons carrying common risk
alleles of disease susceptibility genes. Here we demonstrate that an interaction between a …