User profiles for "author:Thaddeus S Stappenbeck"
Thaddeus S. StappenbeckCleveland Clinic Verified email at ccf.org Cited by 33197 |
[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
The role of stromal stem cells in tissue regeneration and wound repair
TS Stappenbeck, H Miyoshi - Science, 2009 - science.org
The process of wound repair in epithelium-lined organs of mammals is complex and is
influenced by numerous secreted factors including cytokines, growth factors, and …
influenced by numerous secreted factors including cytokines, growth factors, and …
Genetics and pathogenesis of inflammatory bowel disease
TC Liu, TS Stappenbeck - Annual Review of Pathology …, 2016 - annualreviews.org
We are currently in an exciting time when our understanding of genetic underpinnings of
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel …
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel …
[PDF][PDF] A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility
Despite the accepted health benefits of consuming dietary fiber, little is known about the
mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk …
mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk …
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
K Cadwell, JY Liu, SL Brown, H Miyoshi, J Loh… - Nature, 2008 - nature.com
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small
intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene …
intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene …
[PDF][PDF] The colonic crypt protects stem cells from microbiota-derived metabolites
GE Kaiko, SH Ryu, OI Koues, PL Collins… - Cell, 2016 - cell.com
In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor
cells at their base. The mammalian intestine also harbors a diverse array of microbial …
cells at their base. The mammalian intestine also harbors a diverse array of microbial …
Peripheral education of the immune system by colonic commensal microbiota
The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity,
is facilitated by the education of T cells in a specialized organ, the thymus, in which self …
is facilitated by the education of T cells in a specialized organ, the thymus, in which self …
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
TS Stappenbeck, LV Hooper… - Proceedings of the …, 2002 - National Acad Sciences
The adult mouse intestine contains an intricate vascular network. The factors that control
development of this network are poorly understood. Quantitative three-dimensional imaging …
development of this network are poorly understood. Quantitative three-dimensional imaging …
[HTML][HTML] Disease-specific alterations in the enteric virome in inflammatory bowel disease
Decreases in the diversity of enteric bacterial populations are observed in patients with
Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these …
Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these …
[HTML][HTML] Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
It is unclear why disease occurs in only a small proportion of persons carrying common risk
alleles of disease susceptibility genes. Here we demonstrate that an interaction between a …
alleles of disease susceptibility genes. Here we demonstrate that an interaction between a …